Extrude Hone Corporation

Other

Incyte Genomics, Inc.

James Randall Gilmore

Lawrence J Rhoades

Susan G Stuart

Laura L Stuve

Steven Daniel

Chris Brinegar

Nigel Walker

Michael Johnson

The present invention is based on the practice of abrasive machining with no sealed working chamber by the employment of a visco-elastic abrasive medium, behaving predominantly as an elastic solid at the applied strain of the orbital working motion, and applying orbital or other relative working motion to produce strain rates which bring the medium into a predominantly elastic deformation and often near, but not to exceed, the compressive stress limit at the strain rate employed. The preferred visco-elastic abrasive medium is a rheopectic poly(boro-siloxane) filled with viscosity increasing stiffening agents and high loadings of the abrasive of choice and relatively mono amounts of plasticizers. The system is operated in an open chamber under applied strain rates such that at least 50%, particularly about 50 to 99%, and preferably about 80 to 95%, of the deflection of the medium under the conditions of operation occurs by elastic deformation and is elastically recovered, and less than 50% particularly about 1 to 50%, preferably about 5 to 20%, of the deflection of the medium occurs by fluid or plastic flow.

Abrasive polishing composition

A method for producing, from a blank, restrictive tooling for use in an orbital polishing machine involves urging one of either the workpiece or the blank along a predetermined path against the other to physically impart a proportioned contour of the workpiece into the blank, thereby producing the restrictive tooling. Using this method, the same orbital polishing machine may be used to produce the restrictive tooling and to subsequently polish the workpiece.

Self-forming tooling for an orbital polishing machine and method for producing the same

Abrasive polishing apparatus

The present invention relates to polynucleotides comprising genes that regulate cell proliferation. The present invention also relates to a method for diagnosing or monitoring the treatment of a disease characterized by the altered expression of genes that regulate cell proliferation in a sample.

Detection of altered expression of genes regulating cell proliferation

The present invention is based on the practice of abrasive machining with no sealed working chamber by the employment of a visco-elastic abrasive medium, behaving predominantly as an elastic solid at the applied strain of the orbital working motion, and applying orbital or other relative working motion to produce strain rates which bring the medium into a predominantly elastic deformation and often near, but not to exceed, the compressive stress limit at the strain rate employed. The preferred visco-elastic abrasive medium is a rheopectic poly(boro-siloxane) filled with viscosity increasing stiffening agents and high loadings of the abrasive of choice and relatively minor amounts of plasticizers. The system is operated in an open chamber under applied strain rates such that at least about 50%, particularly about 50 to 99%, and preferably about 80 to 95%, of the deflection of the medium tinder the conditions of operation occurs by elastic deformation and is elastically recovered, and less than 50%, particularly about 1 to 50%, preferably about 5 to 20%, of the deflection of the medium occurs by fluid or plastic flow.

Abrasive polishing method, apparatus and composition

Investment casting molds, and particularly mold cores, are formed of sintered ceramics to near net shape and are then machined to net shape, dimensions and surface finish, by ultrasonic machining with formed tools having the final configuration in mirror image form. Form machining of fired mold shells and cores is rapid, precise, readily controlled, and can produce castings of exceptional accuracy of shape, dimensions and surface finish.

Investment casting molds and cores

Friction welding is preformed by linear or non-rotating orbital motion in which both parts to be joined by friction welding are moved in identical paths, out of phase to produce friction until welding temperature is attained, and then in phase, with the parts registered in alignment, during the bonding phase. Because the registered, in phase control of the mechanism is attainable with great certainty and rapidity, friction welding with a far higher precision and accuracy of alignment is attained. The high precision and accuracy of the technique permits application of friction welding to fabrication of parts, such as turbine engines, not usually made by such techniques. A preferred apparatus for practice of the invention involves an opposed pair of orbital tables (110 and 120), on which parts to be joined are mounted and fixed in place by mounts 113 and 123). The parts are aligned and registered and drives (111 and 121) then cause the parts to orbit while they are pressed together by pressure means (14), until friction heats the joint surfaces to welding temperatures.

Friction welding and welds made by friction

Methods and apparatus for the introduction of foreign substances, such as recombinant DNA, into living cell interiors is disclosed. The desired substance to be introduced is dissolved or suspended in water or another suitable liquid to form a solution which is then nebulized and frozen to produce ice particles. These ice particles are accelerated toward and impact upon a target tissue where some of the particles impregnate at least some cells in the target tissue without killing the cells. Following impregnation, the ice particles melt, leaving behind the desired substance in the protoplasm of the bombarded cell.

Ice-mediated introduction of substances into biological material

A structure for quickly and accurately aligning an ultrasonic tool assembly on an ultrasonic machine tool table in which a mounting is provided on said table and an engaging device is secured to said tool assembly which can be made to quickly engage the mounting to accurately align the tool assembly.

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Ligonier, PA, United States of America

James Randall Gilmore