Usv Pharmaceutical Corporation

James R Shroff

Bernard Loev

Rohit M Desai

Howard Jones

Peter P Cervoni

Unsaturated heterocyclic dihydropyridines of the formula: ##STR1## wherein the substituents defined herein have been found to have useful antihypertensive activity.

Antihypertensive 4[(3-alkylamino-2-hydroxypropyl)-oxyiminomethyl

The compounds of the formula: ##STR1## wherein each of the substituents is as defined herein are useful anti-hypertensive agents.

N-Substituted 1,4-dihydropyridines and pharmaceutical compositions

New dihydropyridines are described. These compounds are useful in the treatment of asthma.

Dihydropyridines and their use in the treatment of asthma

Compounds of the formula: ##STR1## which are useful as antihypertensive agents are disclosed.

N-Substituted 1,4-dihydropyridazines and pharmaceutical compositions

Compounds of the formula ##STR1## wherein R is hydrogen, alkyl, alkoxy, halo, amino, alkylamino, dialkylamino, hydroxy, nitro, trifluoromethyl, mercapto, or alkylmercapto, and may be the same or different,

N-(-2-Pyrimidinyl)-4-aryl-4-[N'-(alkylamino alkyl)]-piperidinamide

Compounds of the formula ##STR1## wherein each of R, R.sub.1 and R.sub.2 is independently H, alkyl, alkenyl, alkoxy, halo, hydroxy, trifluoromethyl, amino, alkylamino, cyano and nitro;

Naphthyridone derivatives

Iminobenzyl dihydropyridines of the formula ##STR1## wherein, each R is alkyl, alkenyl, alkynyl, cycloalkyl, aryl, aralkyl, sulfonamido, halogen, alkoxy, alkenyloxy, alkynyloxy, cyano, hydroxy, acyloxy, nitro, amino, alkylmercapto, alkylamino, alkanoylamino, carbalkoxyamino, carboxy, methanesulfonyl, carbalkoxy or trifluoromethyl;

Antihypertensive amines

Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are independently hydrogen, lower alkyl, phenyl or phenyl-lower alkyl,

Pyridylacyl-hydroxamates

Compounds of the formula ##STR1## wherein R is lower alkyl, phenyl, lower alkenyl, cycloalkyl and substituted phenyl;

Substituted benzylidene imines

Antihypertensive compounds of the formula ##STR1## wherein R.sub.5 is H, alkyl, aryl, halo, lower alkoxy, nitro amino, alkylmercapto, cyano, carboxy, carbalkoxy, sulfamyl, trifluoromethyl, hydroxy, acyloxy, methanesulfonyl, alkylamino or acylamino; and each R.sub.1 and R.sub.2 is alkyl; wherein the alkyl, alkoxy and aryl groups contain up to 10 carbon atoms and non-toxic, pharmaceutically-acceptable acid addition salts thereof.

Antihypertensive pyridines and compositions

Compounds of the structure ##STR1## wherein R is lower alkyl or ##STR2## WHEREIN R.sub.1 and R.sub.2 are hydrogen, lower alkyl, lower alkoxy, hydroxy, amino, nitro, halogen and trifluoromethyl and may be the same or different, and m and n are integers from 0 to 1 have potent hypotensive activity.

Growing community of inventors

Riverside, CT, United States of America

James R Shroff