Targacept, Inc.

Other

Bristol-myers Squibb Pharma Company

Catalyst Biosciences, Inc.

James R Moore

Julio A Munoz

John Genus

Lilian Alicia Radesca

Michael B Maurin

Shelley R Rabel

Julia C Moore

Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof compositions that are hydroxybenzoate salts of E-metanicotine-type compounds. The formation of hydroxybenzoate salts of the E-metanicotine compounds is also useful in purifying the E-metanicotine compounds, as the hydroxybenzoate salts tend to crystallize out, leaving impurities such as Z-metanicotine compounds, and compounds where the double bond has migrated, in solution. If desired, the hydroxybenzoate salts can be converted to either the free base (the E-metanicotine compound) or to another pharmaceutically acceptable salt form.

Hydroxybenzoate salts of metanicotine compounds

A decorating tip cleaning apparatus includes a first frame member having opposed front and rear edges and a second frame member having opposed front and rear edges. The rear edges of the frame members are pivotally coupled together such that the first and the second frame members are movable between a closed configuration at which the front edges, respectively, are generally adjacent one another and an open configuration at which the front edges, respectively, are separated from one another. The first and second frame members include a mesh material extending between respective front and rear edges. The mesh material of the first frame member defines a plurality of apertures spaced apart from one another, each aperture being configured to receive a decorating tip partially therethrough. Each aperture is configured to receive only a portion of a respective decorating tip.

Decorating tip cleaning apparatus

Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof compositions that are hydroxybenzoate salts of E-metanicotine-type compounds. The formation of hydroxybenzoate salts of the E-metanicotine compounds is also useful in purifying the E-metanicotine compounds, as the hydroxybenzoate salts tend to crystallize out, leaving impurities such as Z-metanicotine compounds, and compounds where the double bond has migrated, in solution. If desired, the hydroxybenzoate salts can be converted to either the free base (the E-metanicotine) or to another pharmaceutically acceptable salt form.

This invention combines several processes into on easy to use product. The glass sphere dramatically enhances the aeration procedure by gently exposing air to thin waves of wine as wine passes over the surface of the sphere. The integrated filter provides a larger surface than normally found in wine filtration devices. The supporting structure secures the decanter in such a way that consumers can easily dispense wine without handling a wine bottle or conventional decanter.

Aerating decanter with dispensing valve

The potent reverse transcriptase inhibitor Efavirenz is produced in crystalline form. Crystalline Efavirenz exists in several physical forms which are-designated Forms 1, 2, 3 and 4, and are characterized by x-ray powder diffraction and differential scanning calorimetry. Pharmaceutical compositions and methods are useful for the treatment of the human immunodeficiency virus (HIV).

Crystalline Efavirenz

A toothbrush adapted to serve as an instructional aid to encourage toothbrushing and to reinforce recommended toothbrushing technique. The toothbrush includes a body having an electrical subassembly incorporating a visual indicator such as a light or a light emitting diode, and a switching unit within the electrical subassembly for selectively activating the visual indicator only when the toothbrush is being used according to recommended toothbrushing technique. An alternate embodiment of the toothbrush includes a separate toothbrush head insert and a separate handle for receiving the toothbrush head insert which can therefore be removed and replaced. A further alternate embodiment of the invention includes an aural indicator selectively activated by the electrical subassembly during recommended toothbrushing technique.

Growing community of inventors

Newark, DE, United States of America

James R Moore