Merrell Dow Pharmaceuticals

Other

Neurocrine Biosciences, Inc.

Merrell Pharmaceuticals, Inc.

Eli Lilly and Company

Indiana University

The Dow Chemical Company

Bristol-myers Squibb Compnay

Hoechst Marion Roussel

James R McCarthy

Donald Paul Matthews

Charles Q Huang

Jeffrey Paul Whitten

Michael L Edwards

Chen Chen

Mustapha Haddach

Charlotte L Barney

Esa T Jarvi

Thomas R Webb

Robert J Broersma

Terence J Moran

Keith M Wilcoxen

Thomas M Bargar

Zhiqiang Guo

Jeffrey S Sabol

Leonard Larry Winneroski, Jr

Christopher J Rito

Yanping Xu

Alexander Glenn Godfrey

Nellikunja J Prakash

Dawn Alisa Brooks

James R McConnell

Richard E Donaldson

Sarah Beth Jones

Scott L Harbeson

Dominic P Behan

Brian Dyck

Ana Belen Bueno Melendo

Maria Rosario Gonzalez-Garcia

Zhengyu Liu

Marion W Wannamaker

Michael Edward LeTourneau

Robert Broersma, Jr

Donald L Trepanier

Jodie Nelson

Philip E Erickson

Robert Duquid

Philippe Bey

Alan J Bitonti

Robert J Ardecky

Timothy Alan Shepherd

John L Krstenansky

Nathan Bryan Mantlo

Marion Lanier

Lawrence C Creemer

John S Tyhonas

Niall S Doherty

Robert Dean Dally

Patric James Hahn

Todd Jonathan Kohn

Timothy Barrett Durham

David Michael Bender

Kenneth James Henry, Jr

Paul LaMarche

Stephen H Buck

Jon Andre Erickson

Paul J Widner

Shu-Hui Chen

Howard Barff Broughton

Yun Feng Xie

Pierre Yves Michellys

Robert Duguid

Albert Schuster

Kevin Kirkham

Ronald Walsh

Mustapha Hadduch

Mellikunja J Prakash

Jeffrey A Wolos

Chester F Hassman, Iii

John Y Ramphal

An improved insulated sleeve for prolonging the period during which a chilled beverage can is able to maintain a cool condition is disclosed. The sleeve is generally cylindrical and made from an insulating material and defines a side wall, a floor and an open end. The sleeve further defines a notch which extends at least horizontally through the floor. In another aspect, the invention discloses a method of using the insulated sleeve.

Method of using muffletop can cooler

The invention described herein pertains to processes and intermediates for preparing indole containing pharmaceuticals, particularly to processes and intermediates for preparing selective estrogen receptor modulators, such as bazedoxifene.

Processes and intermediates for preparing indole pharmaceuticals

Processes and intermediates for preparing linezolid, and pharmaceutically acceptable salts thereof, are described herein.

Processes for preparing linezolid

Processes and intermediates for preparing rivaroxaban, and analogs and derivatives thereof, and pharmaceutically acceptable salts of each of the foregoing, are described herein.

Processes for preparing Rivaroxaban

A multistage sealed pump is provided for use in an X-ray tube cooling system which is substantially more efficient than pumps of known construction and which provides substantially higher pumping pressure at lower motor current than conventionally. Cooling liquid can be transferred from stage to stage by interconnecting tubing external of the housing or within the housing, through a hollow motor shaft, or through the motor casing. In another embodiment, the multiple impellers can be directly mounted on a shaft extending from a single end of the motor.

Multistage sealed coolant pump

The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, methods of using the same, processes for preparing the same, and intermediates thereof. 

Cyclopropanecarboxylate esters of acyclovir

The present invention provides BACE inhibitors of Formula (I); methods for their use and preparation, and intermediates useful for their preparation. 

3-(2-acylamino-1-hydroxyethyl)-morpholine derivatives and their use as bace inhibitors

The present invention provides BACE inhibitors of Formula (I): methods for their use, and intermediates and methods for their preparation. 

Amides as BACE inhibitors

Compounds represented by the following structural formula (I), and pharmaceutically acceptable salts, solvates and hydrates thereof, wherein: n is 2, 3, or 4 and W is CH, CH(OH), C(O) or O; R1 is an unsubstituted or substituted aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryl-alkyl, heteroaryl-alkyl, cycloalkyl-alkyl, or t-butyl; R2 is H, alkyl, haloalkyl or phenyl; Y is an unsubstituted or substituted thiophen-2,5-diyl or phenylene; R3 is alkyl or haloalkyl; R4 is a substituted or unsubstituted phenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, quinolyl, pyridyl or benzo[1,3]dioxol-5-yl group; and R5 is H, alkyl, or aminoalkyl; are useful for modulating a peroxisome proliferator activated receptor, particularly in the treatment of diabetes mellitus. 

Peroxisome proliferator activated receptor agonists

Novel compounds that are modulators of PPAR receptors, and pharmaceutically acceptable salts, solvates and hydrates thereof, processes for making the compounds, pharmaceutical compositions containing the compounds, or pharmaceutically acceptable salts, solvates and hydrates thereof 

Oxazolyl-aryloxyacetic acid derivatives and their use as PPAR agonists

This invention concerns compounds of formula including the stereoisomers and the pharmaceutically acceptable acid addition salt forms thereof, wherein Ris NRRor OR; Ris Calkyl, Calkyloxy or Calkylthio; Ris hydrogen, Calkyl, Calkylsulfonyl, Calkylsulfoxy or Calkylthio; Ris hydrogen, Calkyl, mono- or di(Ccycloalkyl)methyl, Ccycloalkyl, Calkenyl, hydroxyCalkyl, CalkylcarbonyloxyCalkyl or CalkyloxyCalkyl; Ris Calkyl, mono- or di(Ccycloalkyl)methyl, ACH, CalkyloxyCalkyl, hydroxyCalkyl, Calkenyl, thienylmethyl, furanylmethyl, CalkylthioCalkyl, morpholinyl, mono- or di(Calkyl)aminoCalkyl, di(Calkyl)amino, CalkylcarbonylCalkyl, Calkyl substituted with imidazolyl; or a radical of formula &#x2014;Alk&#x2014;O&#x2014;CO&#x2014;Ar; or Rand Rtaken together with the nitrogen atom to which they are attached may form an optionally substituted pyrrolidinyl, piperidinyl, homopiperidinyl or morpholinyl group; having CRF receptor antagonistic properties; pharmaceutical compositions containing such compounds as active ingredients; methods of treating disorders related to hypersecretion of CRF such as depression, anxiety, substance abuse, by administering an effective amount of a compound of formula (I).

Pyrazolopyrimidines as CRF receptor antagonists

A multistage sealed pump is provided for use in an X-ray tube cooling system which is substantially more efficient than pumps of known construction and which provides substantially higher pumping pressure at lower motor current than conventionally. The pump employs multiple impellers which are plumbed in series and which are directly coupled to an electrical motor which with the impellers is submerged and runs in the coolant liquid. The impellers and motor are sealed within a housing and the pump unit is hermetically sealed, with no rotatable shaft seals being used or required. In one embodiment, the multistage pump employs a motor having oppositely extending motor shaft ends, with one or more impellers on each end of the motor shaft. The cooling liquid can be transferred from stage to stage by interconnecting tubing external of the housing or within the housing, through a hollow motor shaft, or through the motor casing. In another embodiment, the multiple impellers can be directly mounted on a shaft extending from a single end of the motor.

An interior shield that is located immediately beneath the lid of the storage compartment of a vehicle to prevent interior objects from damaging the lid. The storage compartment can be in the front of the vehicle or in the rear of the vehicle. The shield is made of strong lightweight material such as ABS plastic which can be removably attached to fit over the interior of the lid of the storage compartment by attaching means such as plastic clips.

Interior shield on the lid of the trunk of a vehicle to prevent the lid of the trunk from being damaged by the contents contained beneath the lid

CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, such as stroke.

CRF receptor antagonists and methods relating thereto

Growing community of inventors

West Chester, OH, United States of America

James R McCarthy