Pfizer Corporation

James R Hauske

Hiroshi Maeda

Walter P Cullen

Junsuke Tone

Arthur A Nagel

Gary R Schulte

Gloria J Kostek

Robert L Rosati

Kimberly O Cameron

Gene M Bright

Frank C Sciavolino

Eric R Larson

Paul Da Silva-Jardine

Benzothiophenes and related compounds as estrogen agonists

Macrolides of formula (I) and methods of treatment of resistance to transplantation, fungal infections and auto-immune diseases such as rheumatoid arthritis and psoriasis using said macrolides of formula (I), ##STR1## wherein n is 1 or 2; A and B are taken together and form .dbd.O or A and B are taken separately and are each H or A is OH and B is H; R.sup.1 is a desosamino group; R.sup.2 is OH or a desosaminyloxy group; and R.sup.3 is an alkyl or allyl group.

Desosamino derivatives of macrolides

Desosamino derivatives of macrolides as immunosuppressants and

Macrolides of formula (I) and methods of treatment of resistance to transplantation, fungal infections and autoimmune diseases such as rheumatoid arthritis and psoriasis using said macrolides of formula (I), ##STR1## wherein n is 1 or 2; A and B taken together form .dbd.O or A and B taken separately are each H or A is OH and B is H; R.sup.1 is a group of the formula ##STR2## R.sup.2 is OH or a desosaminyloxy group; and R.sup.3 is an alkyl or allyl group.

Phosponated derivatives of macrolides

An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Streptomyces sp. ATCC 53862. This novel antibiotic is useful as an anticoccidial in chickens, in the prevention or treatment of swine dysentery, and as a growth promotant in cattle and swine.

Acid polycyclic ether antibiotic

An antibiotic complex, containing three major components, has been isolated from fermentations of a new strain of the microorganism Streptomyces hirautus. The major components are new, neutral, macrolide antibiotic compounds, which are useful as antibacterial agents against certain gram-positive bacteria.

Process for preparing macrolide antibiotics by culturing streptomyces

Acidic polycyclic ether antibiotic

Antibacterial 12,12'-anhydro-9R-hydroxy-9-deoxoerythromycin A derivatives, intermediate therefor and process of 12,12'-dehydration.

C.12 modified erythromycin A derivatives

An antibiotic complex, containing three major components, has been isolated from fermentations of a new strain of the microorganism Streptomyces hirsutus. The major components are new, neutral, macrolide antibiotic compounds, which are useful as antibacterial agents against certain gram-positive bacteria.

Neutral macrolide antibiotics from Streptomyces

Certain novel 9-deoxo-4'-deoxy-4'-amino-9a-aza-9a-homoerythromycin A derivatives; a method of treating a bacterial infection in a mammalian subject using the novel erythromycin A derivatives; pharmaceutical compositions containing the novel erythromycin A derivatives; and intermediates and processes for making the novel erythromycin A derivatives.

9.alpha.-Aza-9.alpha.-homoerythromycin compounds, pharmaceutical

Certain novel 9-deoxo-4'-deoxy-4'-amino-9a-aza-9a-homoerythromycin A derivatives; a method of treating a bacterial infection in a mammalian subject using these novel erythromycin A derivatives; pharmaceutical compositions containing the novel erythromycin A derivatives; and intermediates and processes for making the novel erythromycin A derivatives.

Antibacterial 9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin D, pharmaceutically-acceptable salts thereof, pharmaceutical compositions comprising antibacterially-effective amounts thereof, a method of treatment of bacterial infections with antibacterially effective amounts thereof, and intermediates for the synthesis thereof from erythromycin D.

Azahomoerythromycin D derivative and intermediates therefor

The reaction product of dimethyl diazomethylphosphonate with 4'-deoxy-4'-oxo-oleandomycin and erythromycin A derivatives as antibacterial agents, and intermediates leading thereto.

Semi-synthetic macrolides

Antibacterial macrolides derived from 9-dihydro-11,12-O-isopropylidene-erythromycin A and 9-dihydro-11,12-O-isopropylidene-4'-epi-erythromycin A.

9-Dihydro-11,12-ketal derivatives of erythromycin A and epi-erythromycin

The reaction product of dimethyl diazomethylphosphonate with 4'-deoxy-4'-oxo-oleandomycin and erythyromycin A derivatives as antibacterial agents.

Growing community of inventors

East Lyme, CT, United States of America

James R Hauske