Bristol-myers Squibb Compnay

Bristol-myers Company

James R Epperson

Katherine S Takaki

Graham Johnson

Joseph P Yevich

Brett T Watson

Stephen R Bertenshaw

Ronald J Mattson

Graham S Poindexter

Dalton King

Lawrence R Marcin

John D Catt

Daniel J Keavy

Mendi A Higgins

Jonathan L Ditta

George N Karageorge

Derek John Denhart

Jeffrey A Deskus

Li-Quang Sun

Karen L Leboulluec

Cyclopropylindole derivatives as selective serotonin reuptake inhibitors

Novel benzofuran and dihydrobenzofuran derivatives which have a binding affinity for the human melatonin receptor and, therefore, are useful as melatonergic agents.

Arylalkylbenzofuran derivatives as melatonergic agents

There is provided novel aryloxyanilides and related compounds of the formula ##STR1## wherein R.sup.1 is --OR, --CO.sub.2 R, or halogen with R being C.sub.1-4 alkyl;

Aryloxyanilides and related compounds

Novel polycyclic ethyl alkylamides of formula I are active as melatonergic agents. ##STR1## wherein Z=CH (when a double bond is present) or (CH.sub.2).sub.n, wherein n is 1-4;

Polycyclic ethyl alkylamide melatonergic agents

There is provided novel biphenylamido derivatives of the formula ##STR1## wherein Z is ##STR2## and Y is H or Z is H and Y is ##STR3## n is 0 or 1; R is C.sub.1-6 alkyl;

Biphenylamido derivatives as melatonergic agents

Novel substituted fluorene compunds of Formula I are active as melatonergic agents: ##STR1## wherein: X=H, halogen, OH or OZ;

Ethylamido fluorenes and improved method of making same

Certain tetralinyl- and indanyl-ethylamides are useful central nervous system agents.

Tetralinyl-and indanyl-ethylamides

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Cromwell, CT, United States of America

James R Epperson