Alkermes Controlled Therapeutics, Inc.

Alkermes Pharma Ireland Limited

James R Dasch

M Gary I Riley

Henry R Costantino

Stephen E Zale

Joyce M Hotz

Paul A Burke

Susan A Steitz-Abadi

The invention relates to compositions and methods for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein a biologically active polypeptide, and a corticosteroid to modify the release profile and provide increased bioavailability.

Microencapsulation and sustained release of biologically active polypeptides

The present invention relates to a method for the sustained release in vivo of a biologically active agent comprising administering to a subject in need of treatment an effective amount of a sustained release composition comprising a biocompatible polymer having the biologically active agent incorporated therein, and a bisphosphonate wherein the bisphosphonate compound is present in an amount sufficient to modify the release profile of the biologically active agent from the sustained release composition. Pharmaceutical compositions suitable for use in the method of the invention are also disclosed.

Method of modifying the release profile of sustained release compositions

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Needham, MA, United States of America

James R Dasch