Oregon State University

Outset Medical, Inc.

Home Dialysis Plus, Ltd.

Tyco Healthcare Group LP

James R Curtis

Richard Budd Peterson

Goran Jovanovic

Julie S Wrazel

Ladislaus Nonn

Robbie Ingram-Goble

Anna Evelyn Garrison

Luke W Fisher

Hailei Wang

Richard Todd Miller

M Kevin Drost

Bruce W Johnson

Eric Kenneth Anderson

Donald D Solomon

F Mark Ferguson

David Lynn Thorne

Eugene E Weilbacher

Gale Harrison Thorne, Jr

Mark A Nelson

Richard Fiser

Charles V Owen

Brian Kevin Paul

David M Browning

Roy L Barrus

Dean Hu

Michael E Hogard

Gale H Thorne

Sundar V Atre

Michael Thorne

Alana Anderson

Steven Brown

Gopi Lingam

James Ritson

Shih-Paul Chen

Dalibor Jan Smejtek

Kevin Drost

Alana Warner-Tuhy

Peter Velasco Obico

Steven M Miller

Goran Nadezda Jovanovic

Eric K Anderson

Michael Edward Hogard

Richard T Miller

Wrazel Julie S S

Dialysis systems and methods are described which can include a number of features. The dialysis systems described can be to provide dialysis therapy to a patient in the comfort of their own home. The dialysis system can be configured to prepare purified water from a tap water source in real-time that is used for creating a dialysate solution. The dialysis systems described also include features that make it easy for a patient to self-administer therapy. For example, the dialysis systems include disposable cartridge and patient tubing sets that are easily installed on the dialysis system and automatically align the tubing set, sensors, venous drip chamber, and other features with the corresponding components on the dialysis system. Methods of use are also provided, including automated priming sequences, blood return sequences, and dynamic balancing methods for controlling a rate of fluid transfer during different types of dialysis, including hemodialysis, ultrafiltration, and hemodiafiltration.

Dialysis system and methods

Certain disclosed embodiments concern systems and methods of preparing dialysate for use in a home dialysis system that is compact and light-weight relative to existing systems and consumes relatively low amounts of energy. The method includes coupling a household water stream to a dialysis system; filtering the water stream; heating the water stream to at least about 138 degrees Celsius in a non-batch process to produce a heated water stream; maintaining the heated water stream at or above at least about 138 degrees Celsius for at least about two seconds; cooling the heated water stream to produce a cooled water stream; ultrafiltering the cooled water stream; and mixing dialysate components into the cooled water stream in a non-batch process.

Fluid purification system

A dialysis system includes a filtration system capable of filtering a water stream, a water purification system capable of purifying said water stream in a non-batch process, a mixing system capable of producing a stream of dialysate from mixing one or more dialysate components with the water stream in a non-batch process, and a dialyzer system. The dialyzer may be a microfluidic dialyzer capable of being fluidly coupled to the stream of dialysate and a blood stream.

Dialysis system

Systems and methods are disclosed for performing hemodialysis that include fluid handling systems that provide accurate control over the type and level of hemodialysis being performed. The system includes a first pump for pumping dialysate into a dialyzer and a second pump for pumping dialysate out of the dialyzer. The system also includes a third pump that provides improved control of a level of ultrafiltration, hemodiafiltration, or both.

Dialysis system with ultrafiltration control

Disclosed herein are water purification and supply systems for medical devices and methods of using. In an embodiment, the system includes a dialysis system including a filtration system capable of filtering a water stream, a water purification system capable of purifying the water stream in a non-batch process, a mixing system capable of producing a stream of dialysate from mixing one or more dialysate components with the water stream in a non-batch process, and a dialyzer system. The dialyzer may be a microfluidic dialyzer capable of being fluidly coupled to the stream of dialysate and a blood stream. The water purification system includes an RO filter, a proportioning valve, a heater, first and second heat exchangers, and a throttle valve

Ultra-pasteurization for dialysis machines

Disclosed are systems and methods of preparing dialysate for use in a home dialysis system that is compact and light-weight relative to existing systems and consumes relatively low amounts of energy. The method includes coupling a household water stream to a dialysis system; filtering the water stream; heating the water stream to at least about 138 degrees Celsius in a non-batch process to produce a heated water stream; maintaining the heated water stream at or above at least about 138 degrees Celsius for at least about two seconds; cooling the heated water stream to produce a cooled water stream; ultrafiltering the cooled water stream; and mixing dialysate components into the cooled water stream in a non-batch process.

The present invention provides methods and apparatus for cleansing blood through hemodialysis by the process of diffusion across a membrane into dialysate. This dialyzer also removes solutes from the blood by a process of convection, where fluid and dissolved solutes pass through the membrane out of the blood. In one embodiment in accordance with the present invention, the MECS dialyzer uses a counter-flow between the dialysate and blood through a plurality of microchannels. The dialyzer comprises a plurality of flat semi-permeable membranes interleaved between microchannel sheets to define a plurality of flow channels. The stack of membranes and microchannel sheets are aligned and consolidated to form the MECS dialyzer. The MECS dialyzer acts as a flow manifold with ports and headers to collect the blood and dialysate and direct them to and from the microchannels.

MECS dialyzer method

The present invention is related to hemodialysis, and more particularly, to a dialyser with improved efficiency of mass transfer across a dialysis membrane utilizing microchannel separation provided in accordance with embodiments of the present invention. In accordance with an embodiment, a dialyzer is provided comprising a plurality of semipermeable membrane sheets and a plurality of flow separators. The membrane sheets and flow are arranged in alternating configuration and coupled into a laminae stack defining a plurality of parallel microchannel layers. Each microchannel layer comprises a plurality of first microchannels and a plurality of second microchannels. The first and second microchannels of each microchannel layer are in fluid communication with each other via one of the plurality of membrane sheets therebetween. The MECS dialyzer is characterized as having a high surface to volume ratio and a high mass transfer coefficient.

MECS dialyzer

Medical needle shield apparatus for covering a needle after use. In embodiments of this invention a shield with two or more segments hingedly connected to each other is movable from a retracted position where the needle is exposed, to an extended position where the shield extends beyond the end of the needle. The needle is affixed in a hub of a medical needle device, and the shield is articulated to the hub. At least one of the two or more segments has an open orifice through which the needle passes to form an axis of intersection about the needle. The shield includes a channel for covering the needle when the shield is linearly extended. One or more locks associated with one or more of the segments secures one or more of the segments relative to the shield in the extended position. A latch is also disposed on the distal segment for securing the distal segment relative to the shield when in the extended position. The number of hingedly connected segments depends upon the needle length and device length required to extend the shield beyond the distal end of the needle.

Safety shield for medical needles

Growing community of inventors

Portland, OR, United States of America

James R Curtis