Battelle Memorial Institute

Canon Kabushiki Kaisha

James R Busch

Theodore J Ronningen

Andrew P Bartko

Ryan W Daly

Matthew S Young

David R Chase

Rodney S Black

Richard William Ridgway

Anthony A Boiarski

Carl M Verber

Van Earl Wood

A small area electrostatic aerosol collector combines electrostatic collection of aerosol particles and electrohydrodynamic spraying of fluid so that a sample collected electrostatically can have fluid applied thereto. The fluid may assist with disaggregation and/or desalinization of biological material collected onto a sample substrate. A controller associated with the collector may control an electrostatic charge device and a spraying device such that the charge device and spraying device may operate in alternating fashion, or the charge device and spraying device may operate simultaneously. Further, mechanical systems are provided, for the disaggregation of particulate clusters collected onto a sample substrate.

Electrohydrodynamic spraying

An apparatus useful in immunoassay of a fluid, light is directed to an optical sensor wherein the light is transmitted to a replaceable optical device that is responsive to index of refraction in a sensing region thereof that is exposed to the fluid. One portion of the light is transmitted via a compensation path that includes the sensing region to a first detector. Another portion of the light is transmitted via a sensing path that includes the sensing region to another detector. In one embodiment a ratioing device receives an output from each detector and provides a signal responsive to the ratio of the outputs. The replaceable optical device typically comprises a pair of channel waveguides in directional coupling arrangement, or a pair of channel waveguides in an interferometer arrangement, or a ridge waveguide having a curved or serpentine path configured so that nonspecific sensing effects are compensated.

Integrated optical compensating refractometer apparatus

A Luneburg lens formed on an optical waveguide has a protective coating to assure stable optical characteristics by preventing changes in the focal length due to exposure to surrounding light and/or moisture. The Luneburg lens may be of As.sub.2 S.sub.3 material provided on a Ti in-diffused LiNbO.sub.3 waveguide.

Protected Luneburg lens

Growing community of inventors

Columbus, OH, United States of America

James R Busch