Eli Lilly and Company

Other

James R Beck

Robert Peter Gajewski

Joseph A Yahner

Ronald E Hackler

Fred L Wright

Stephen A Ackmann

Michael P Lynch

Carole W Price

James A Aikins

Eddie V Tao

Richard K Mann

John D Sunderland

Use of a 4,5-dicarboxy or 5-carboxamido-4-carboxy (or derivatized carboxy)-1-(3,5-disubstituted-phenyl)pyrazole in the production of hybrid seed, and a method for producing 5-carboxamido-4-carboxy-1-(3,5-dimethylphenyl)pyrazole.

Use of gametocidal pyrazoles to produce hybrid seed

A series of triazole compounds having a carboxyalkoxy(thio) group, or a derivative thereof, are useful for regulating the growth of plants, particularly the growth of soybeans.

Plant growth regulating triazoles

Process for preparing

The present invention provides a process for selectively alkylating pyrazoles comprising reacting a 3(5)-cyano-1H-pyrazole-4-carboxylic acid ester with a C.sub.4 -C.sub.8 alkene, or a C.sub.5 -C.sub.6 cycloalkene substituted at the 1-position with a C.sub.1 -C.sub.4 alkyl group, and a strong acid in a solvent which contains a strong electron withdrawing group. Also provided are new 3(5)-cyano-1H-pyrazole-4-carboxylic acid ester useful as starting materials in the process of the invention.

Alkylation of 3(5)-cyano-1H-pyrazole-4-carboxylic acid esters

Pollen formation in cereal grain plants is inhibited by application of a 4,5-dicarboxy or 5-carboxamido-4-carboxy (or derivatized carboxy)-1-(3,5-disubstitutedphenyl)pyrazole. Use of the compounds facilitates the production of hybrid seed.

1-phenylpyrazole-4,5-dicarboxylic acid derivatives, composition

A collapsible shipping container having a base structure provided with upstanding wall catches capable of being received in structurally interfitting relation within respective pockets defined within side walls thereof. A cover structure is provided with depending wall catches which are received within respective upwardly directed pockets of the side walls, thus securing the base structure to the side walls and the cover to the side walls. The cover structure is also provided with shipping catches which are received within shipping catch slots or openings defined within the base structure in the collapsed condition of the shipping container. In this condition the walls are stacked on the base structure and are restrained by the shipping catches and wall catches to secure the walls within the collapsed shipping container for shipping and handling in the collapsed condition thereof. The base structure is provided with spill guard strips which define space perimeters within which are received the lower ends of the wall structures to thus provide an appropriate seal to prevent entry of water and other liquid into the shipping container. The walls of the shipping container interfit at the corners thereof to define structurally interrelated corners that provide exceptional strength and which seal the corner sections against entry of water and other contaminants.

Collapsible shipping container

Pollen formation in cereal grain plants is inhibited by application of a 4-carboxy(or derivative)-1-aryl-5-pyrazolecarboxamide. Production of hybrid seed is facilitated by use of the compounds.

4-carboxy-1-phenyl-5-pyrazolecarboxamides in the production of hybrid

Pollen formation inhibiting 1-phenyl-4-carboxy-5-pyrazolecarboxamides

5-Cyano-1-substituted-1H-pyrazole-4-carboxylic acids and esters useful as intermediates to the corresponding 4-carboxyamide derivatives having herbicidal and algicidal activity.

Cyanopyrazole intermediates

1,5-Disubstituted-1H-pyrazole-4-carboxamide derivatives, useful as herbicides and aquatic algicides.

Herbicidal and algicidal 1,5-disubstituted-1H-pyrazole-4-carboxamides

The present invention is directed to compounds of the formula ##STR1## wherein R.sup.1 is C.sub.1 -C.sub.6 alkyl, C.sub.5 -C.sub.6 cycloalkyl, ##STR2## each of R.sup.2 and R.sup.3 is taken separately and is independently hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.4 alkenyl, C.sub.3 -C.sub.4 alkynyl, C.sub.3 -C.sub.4 cycloalkyl or C.sub.1 -C.sub.3 alkoxy, or

Herbicidal and algicidal 1-aryl-5-cyano-1H-pyrazole-4-carboxamides

The present invention is directed to herbicidal compounds of the formula ##STR1## wherein each R.sup.1 independently is halogen; R.sub.2 is halo or trifluoromethyl; and n is 1-5; with the provisos that when n is 1, R.sup.1 is other than fluorine, and when n is 2 and each R.sup.1 is chlorine, at least one R.sup.1 is located at a para or ortho position on the phenyl ring.

Herbicidal 5-halo-1-halophenyl-1H-pyrazole-4-carbonitriles

3-Phenyl (or meta or para-substituted phenyl)-4-permissibly substituted-5-isothiazolecarboxylic acids, salts, esters and simple amides, used to lower uric acid levels in mammals.

3-Aryl-5-isothiazolecarboxylic acids and related compounds used to lower

Aryl pyrazole carboxylic acids and derivatives thereof, are xanthine oxidase inhibitors in vivo.

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Indianapolis, IN, United States of America

James R Beck