Procyon Pharmaceuticals, Inc.

Baxter Travenol

Alder Research Center Limited Partnership

James Quick

Paul E Driedger

Christine Burns

Judith Andrews

Compositions of matter having protein kinase C-modulatory, anti-inflammatory and other biological activities are disclosed. The compositions are derived from indolactams which have a substituent, containing at least one carbon, at the N position and have ether substitution on the 14-O position.

Protein kinase C modulators. W.

Compositions with protein kinase C-modulatory, anti-inflammatory and other activities are disclosed.

Protein kinase C modulators N

Compounds having anti-inflammatory and other activities are disclosed. The compounds are derived from phorboids of the polyacetate-, diaminobenzyl alcohol-, diacylglycerol- and bryostatin-classes.

Protein kinase C modulators V

Compounds having anti-inflammatory, anti-viral, protein kinase C-modulatory and other activities are disclosed. The compounds are derived from aromatic heterocyclic compounds of the indole, indene, benzofuran and benzothiophene class, each bearing an additional 6-atom chain connecting positions 3 and 4 to form a fused 9-membered ring. This invention is exemplified by 9-deshydroxymethyl-9-carboxyindolactam V.

Protein kinase C modulators. C. indolactam structural-types with

Compounds having anti-inflammatory and other activities are disclosed. The compounds are derived from phorboids of the diterpene- and benzolactam-classes.

Protein kinase C modulators O

Compositions having anti-inflammatory, antiviral and other activities are disclosed. The compositions are derived from phorboids of the polyacetate- and bryostatin-classes.

Polyacetate-derived phorboids having anti-inflammatory and other uses

Compositions with anti-inflammatory and other activitites are disclosed. The compositions are derived from phorboids of the diterpene- and benzolactam-classes.

Protein kinase C modulators Q

Compositions of matter and pharmaceutical compositions having protein kinase C-modulatory, anti-inflammatory, anti-viral and other activities are disclosed. The compounds are derived from tricyclic aromatic heterocyclic compounds incorporating indole, indene, benzofuran and benzothiophene structural elements.

Protein kinase C modulators. E.

Compositions of matter having protein kinase C-modulatory, anti-inflammatory, anti-viral and other activities are disclosed. The compounds are derived from tricyclic aromatic heterocyclic compounds incorporating indole, indene, benzofuran or benzothiophene structural elements.

Protein kinase C modulators. F.

Pharmaceutical compositions having antiviral, antiinflammatory and other activities are disclosed. The compositions are of compounds derived from diterpene phorboids.

Protein kinase C Modulators. L.

Compositions having anti-inflammatory, antiviral and other activities are disclosed. The compositions are derived from phorboids of the diaminobenzyl alcohol- and diacylglycerol-classes.

Protein kinase C modulators. H.

Compounds having anti-inflammatory and other activities are disclosed. The compounds are derived from diterpenes of the phorbol-, resiniferonol- and ingenol-classes.

Protein kinase C modulators. K.

Compositions having protein kinase C-modulatory, anti-inflammatory and other activities are disclosed. The compounds are derived from aromatic heterocyclic compounds of the indole, indene, benzofuran and benzothiophene class.

Protein kinase c. modulators. d.

The present invention relates to new compounds of the general formula: ##STR1## where X is iodine or hydrogen; A is a linking portion; and R is an iodinatable aryl or heteroaryl group having electron donating substituents. These compounds are useful precursors to the iodinated thyroid hormones for radioimmunoassay determination of thyroid hormones in biological fluids.

Growing community of inventors

Lexington, MA, United States of America

James Quick