University of Rochester

University of Iowa Research Foundation

Ironwood Pharmaceuticals, Inc.

Ithaca College

East Carolina University

Sea Pharmaceuticals LLC

James Philip Pearson

Barbara H Iglewski

Andrew S Kende

Richard P Phipps

Everett P Greenberg

Roger Smith

John Jeffrey Talley

Mark G Currie

Kenneth D Tucker

Kendall M Gray

Luciano Passador

Anatol Eberhard

Kevin Sprott

Timothy Claude Barden

Ara Mermerian

G Todd Milne

Charles Kim

Jane Yang

Craig N Zimmerman

Barbara B Chen

Eduardo J Martinez

Brian Cali

Yueh-Tyng Chien

Wayne Schairer

Everett C Pesci

Wilmin Bartolini

Regina Lundigran

Jared B J Milbank

Regina Lundrigan

6-(2-(2H-tetrazol-5-yl)ethyl)-6-fluorodecahydroisoquinoline-3-carboxylic acid and 6-(2-(2H-tetrazol-5-yl)ethyl)-6-fluorodecahydroisoquinoline-3-carboxylic acid hydrocarbyl ester derivatives of formula are disclosed, as are pharmaceutical compositions and methods for the treatment of pain, epilepsy, convulsions, and seizures employing those compositions.

Pharmaceutical compositions of 6-(2-(2H-tetrazol-5-yl)ethyl)-6-fluorodecahydroisoquinoline-3-carboxylic acid and ester derivatives thereof

Indole derivatives that are useful for treating pain, inflammation and other conditions are described. Certain of the compounds are benzyl derivatives and others are benzoyl derivatives. The compounds are substituted at least at the 3 position of the indole.

Indole compounds

Compounds and methods for the treatment of asthma are disclosed. The methods involve mast cell stabilization together with selective inhibition of iNOS. The compounds are combinations of a mast cell inhibiting moiety and an inhibitor of iNOS. An example is: 

Compounds and methods for the treatment of asthma

Indoles that have activity as inhibitors of FAAH are described as are indoles and indole derivatives that have activity as inhibitors of DAO.

Useful indole compounds

Novel bacterial quinolone signal molecules and, more particularly,quinolone signal ('PQS') molecules, e.g., 2-heptyl-3-hydroxy-4-quinolone, and analogs and derivatives thereof are described. Therapeutic compositions containing the molecules, and therapeutic methods, methods of for regulating gene expression, methods for identifying modulators of the autoinducer molecules, and methods of modulating quorum sensing signaling in bacteria using the compounds of the invention are also described.

Autoinducer molecules and uses therefor

The present invention relates to an immunogenic conjugate comprising a carrier molecule coupled to an autoinducer of a Gram negative bacteria The immunogenic conjugate, when combined with a pharmaceutically acceptable carrier, forms a suitable vaccine for mammals to prevent infection by the Gram negative bacteria The immunogenic conjugate is also used to raise and subsequently isolate antibodies or binding portions thereof which are capable of recognizing and binding to the autoinducer. The antibodies or binding portions thereof are utilized in a method of treating infections, a method of inhibiting autoinducer activity, and in diagnostic assays which detect the presence of autoinducers or autoinducer antagonists in fluid or tissue samples.

Methods of treating or preventing an infectious disease using an immunogenic conjugate of a gram-negative bacterial autoinducer molecule

The present invention relates to an immunogenic conjugate comprising a carrier molecule coupled to an autoinducer of a Gram negative bacteria. The immunogenic conjugate, when combined with a pharmaceutically acceptable carrier, forms a suitable vaccine for mammals to prevent infection by the Gram negative bacteria. The immunogenic conjugate is also used to raise and subsequently isolate antibodies or binding portions thereof which are capable of recognizing and binding to the autoinducer. The antibodies or binding portions thereof are utilized in a method of treating infections, a method of inhibiting autoinducer activity, and in diagnostic assays which detect the presence of autoinducers or autoinducer antagonists in fluid or tissue samples.

Method for detecting a gram-negative bacterial autoinducer molecule

Autoinducer molecules, e.g., N-(3-oxododecanoyl)homoserine lactone, forare described. The molecules regulate gene expression in the bacterium. Therapeutic compositions and therapeutic methods involving analogs and/or inhibitors of the autoinducer molecules also are described. The molecules are useful for treating or preventing infection by

Autoinducer molecule

Antibodies raised against immunogenic conjugates of gram-negative bacterial autoinducer molecules

Immunogenic conjugates of Gram-negative bacterial autoinducer molecules

Autoinducer molecules, e.g., N-(3-oxododecanoyl)homoserine lactone, for Pseudomonas aeruginosa are described. The molecules regulate gene expression in the bacterium. Therapeutic compositions and therapeutic methods involving analogs and/or inhibitors of the autoinducer molecules also are described. The molecules are useful for treating or preventing infection by Pseudomonas aeruginosa.

Growing community of inventors

Cambridge, MA, United States of America

James Philip Pearson