Xenon Pharmaceuticals Inc.

Vertex Pharmaceuticals, Inc.

James Philip Johnson, Jr

Sara Sabina Hadida Ruah

Christoph Martin Dehnhardt

Sultan Chowdhury

Alla Yurevna Zenova

Thilo Focken

Michael Edward Grimwood

Robert Joseph Devita

Jean-Christophe Andrez

Kristen Nicole Burford

Syed Abid Hasan

James Roy Empfield

Charles Jay Cohen

Andreas Peter Termin

Brian Richard Bear

Corey Don Anderson

Sara Sabina Hadida-Ruah

Vijayalaksmi Arumugam

David Earl Bogucki

Qi Jia

Michael Scott Wilson

Iuliana Luci Asgian

Shannon Marie Decker

Luliana Luci Asgian

This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.

Benzenesulfonamide compounds and their use as therapeutic agents

This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy and/or epileptic seizure disorders.

Benzenesulfonamide compouds and their use as therapeutic agents

This invention is directed to methods of preparing benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.

The invention relates to amide compounds of formula I and I' or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.

Amides as modulators of sodium channels

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Vancouver, Canada

James Philip Johnson, Jr