Vertex Pharmaceuticals, Inc.

James Philip Johnson

Brian Richard Bear

Corey Don Anderson

Vijayalaksmi Arumugam

Andreas Peter Termin

Sara Sabina Hadida-Ruah

Iuliana Luci Asgian

Sara Sabina Hadida Ruah

Mark Thomas Miller

Jason McCartney

Peter Diederik Jan Grootenhuis

Paul Krenitsky

Bryan A Frieman

Nicole Hilgraf

Joseph Pontillo

Mehdi Numa

Edward Adam Kallel

The invention relates to pyridone amide compounds of formula I and I' or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels:  The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.

Pyridone amides as modulators of sodium channels

The invention relates to compounds of formula I or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: (I). The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain. 

Sulfonamides as modulators of sodium channels

The invention relates to compounds of formula I or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.

Substituted quinolines as modulators of sodium channels

The invention relates to pyridone amide compounds of formula I and I' or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.

Substituted quinoxalines as sodium channel modulators

The invention relates to amide compounds of formula I and I' or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.

Amides as modulators of sodium channels

The invention relates to heterocyclic chromene-spirocyclic piperidine amides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels

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San Diego, CA, United States of America

James Philip Johnson