Nederlandse Organisatie Voor Toegepast-natuurwetenschappelijk Onderzoek Tno

James Peter Robert Day

Daniel Perez Calero

Marijn Sandtke

Tom Duivenvoorde

Jacobus Johannes Frederik Van Veen

Kees Moddemeijer

Frerik Van Beijnum

Gerard Christiaan Jurjen Otter

Jacobus Thomas Wilhelmus Elisabeth Vogels

Dolf Jaap Klomp

Maarten J Scholtes-Timmerman

Ralph Claude Snel

Niels Dijkhuizen

Marcela Pelica Pascoa

A method and device () for making a calibrated measurement of light from an object (E). In a first measurement window (W), object light (L) is received from the object (E) onto a beam splitter () which splits the light into a signal path (Ps) and a reference path (Pr). A first signal (S=T·L·Hs) is measured by a signal detection element () in the signal path (Ps). A second signal (S=R·L·Hr) is measured by a reference detection element () in the reference path (Pr). In a second measurement window (W), calibration light (L) is received onto the beam splitter (). A third signal (S=R·L·Hs) is measured by the signal detection element () in the signal path (Ps). A fourth signal (S=T·L·Hr) is measured by the reference detection element () in the reference path (Pr). A measurement value of the object light (L) is determined based on the measured signals (S,S,S,S).

Radiometric calibration method and device

The present disclosure concerns a measuring probe () for non-invasive in vivo measurement of blood analytes () by Raman spectroscopy. The measuring probe () comprises a housing () having a skin engaging surface (). The housing () comprises a first optical system () arranged for providing source light () to the skin engaging surface () for penetrating a subject's skin () by said source light () for interacting with the blood analytes (). The housing () further comprises a second optical system () arranged for capturing scattered Raman light () from the blood analytes () for measurement of the blood analytes (). The first optical system () is arranged for providing the source light () as a collimated beam () onto the skin ().

Probe, system, and method for non-invasive measurement of blood analytes

The present disclosure concerns a spectrometer () and method for generating a two dimensional spectrum (S). The spectrometer () comprises a main grating () and cross dispersion element (). An imaging mirror () is arranged for reflecting and focussing dispersed radiation (R) from the main grating () towards an image plane (IP) for imaging the two dimensional spectrum (S) onto an image plane (IP) of the spectrometer (). A correction lens () is arranged for correcting optical aberrations in the imaging of the two dimensional spectrum (S) in the image plane (IP). The imaging mirror () and correction lens () have a coinciding axis of cylindrical symmetry (AS).

Spectrometer for generating a two dimensional spectrum

The present disclosure concerns a monolithic spectrometer for spectrally resolving light. The spectrometer comprises a body of solid material having optical surfaces arranged to guide the light along an optical path inside the body. A collimating surface and focusing surface are part of a single surface having a continuous optically functional shape. The surfaces of the body are arranged to have a third or fourth part of the optical path between a grating surface and an exit surface cross with a first part of the optical path between an entry surface and a collimating surface.

Monolithic spectrometer

The present disclosure concerns a method and detector () for detecting an analyte () in a sample volume (), such as nitrosamine in an amine solvent. The method comprises measuring a resonance Raman spectrum (I) with a first light beam (PI) matching an electronic transition of the analyte (). The detection of the analyte is enhanced by measuring an off-resonance Raman spectrum () using a second light beam (P) that is shifted in wavelength at least 10 nm away from the electronic resonance. The resonance Raman signal (S) of the analyte () is isolated from the background (Q, Q) by a difference analysis between the resonance and off-resonance Raman spectra (I, I). The method and detector () can be employed for detecting nitrosamine in a carbon capture process or plant () that employs an amine solvent.

Method and detector for detecting an analyte

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The Hague, Netherlands

James Peter Robert Day