Cibus US LLC

Cibus Europe, B.v.

Boost Biomes, Inc.

James Pearce

Peter R Beetham

Gregory F W Gocal

Christian Schopke

Jerry Mozoruk

Rosa E Segami

Noel Sauer

Noel Joy Sauer

Aura De Schopke

Keith A Walker

Sarah Dumm

Aura Estela Gonzalez Schopke

Robert McBride

Karen Hunt

Jamie Bacher

Veronica Garcia

Gregory FW Gocal

The invention provides to improved methods for the modification of genes in plant cells, and plants and seeds derived therefrom. More specifically, the invention relates to the increased efficiency of targeted gene mutation by combining gene repair oligonucleotides with approaches that enhance the availability of components of the target cell gene repair mechanisms.

Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair

Disclosed herein are biocontrol compositions against plant fungal pathogens and methods of use thereof for the prevention or reduction of crop loss or food spoilage. The biocontrol composition can comprise at least one microbe with anti-fungal activity or a secondary metabolite of the at least one microbe. The methods can comprise application of the biocontrol composition to a plant, a seed, or a produce thereof or to a packaging material used to transport or store the produce.

Microbial compositions for the prevention or reduction of growth of fungal pathogens on plants

Provided herein include methods and compositions for effecting a targeted genetic change in DNA in a cell. Certain aspects and embodiments relate to improving the efficiency of the targeting of modifications to specific locations in genomic or other nucleotide sequences. As described herein, nucleic acids which direct specific changes to the genome may be combined with various approaches to enhance the availability of components of the natural repair systems present in the cells being targeted for modification.

Provided herein include methods and compositions for making targeted changes to a DNA sequence. In various aspects and embodiments, methods and compositions for modifying a DNA sequence in a cell (such as a plant, bacterial, yeast, fungal, algal, or mammalian cell) are provided. In some aspects and embodiments the modification of DNA involves combining gene repair oligonucleotides with approaches that enhance the availability of components of the target cell gene repair mechanisms, such as a DNA cutter.

Targeted gene modification using oligonucleotide-mediated gene repair

Provided are compositions and methods relating to gene and/or protein mutations in transgenic or non-transgenic plants. In certain embodiments, the disclosure relates to mutations in the protoporphyrinogen IX (PPX) gene. In some embodiments the disclosure relates to plants that are herbicide resistant.

Mutated protoporphyrinogen IX oxidase (PPX) genes

Methods and compositions for targeted gene modification

Growing community of inventors

La Jolla, CA, United States of America

James Pearce