Dexcom, Inc.

Mindray Ds Usa, Inc.

Shenzhen Mindray Bio-medical Electronics Co., Ltd.

Metacure Limited

Dexconi, Inc.

James Patrick Thrower

Paul V Goode, Jr

James H Brauker

Apurv Ullas Kamath

Victoria E Carr-Brendel

Mark C Brister

Ben Xavier

Paul V Neale

Sean T Saint

John Nolting

Daniel Steven Kline

Daniel Shawn Codd

Jack Pryor

Jacob S Leach

Nelson Quintana

Vance Swanson

Luis Pestana

Steve Masterson

Thomas F McGee

David Michael Petersen

James R Petisce

Peter C Simpson

Geoffrey C Jawidzik

Michael Robert Mensinger

Mark C Shults

Nicholas Evan Barker

Allan Lee Cameron

David M Chastain

J Michael Dobbles

Arnold Holmquist

James Fidacaro

Jim Wilson

Arpurv U Kamath

Rathbun K Rhodes

John A Guerre

Hilary Farnsworth

Mark Allan Tapsak

Shai Policker

Peter B Schon

Paul Goode

Brian Stonecipher

Rathburn K Rhodes

Anat Kliger

James R Pestisce

Michael J Dobbles

Jr Paul V Goode

Arnold L Holmquist

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Transcutaneous analyte sensor

Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Additional data processing includes evaluating the selected estimative algorithms, analyzing a variation of the estimated analyte values based on statistical, clinical, or physiological parameters, comparing the estimated analyte values with corresponding measure analyte values, and providing output to a user. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk.

Signal processing for continuous analyte sensor

Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.

Systems and methods for replacing signal artifacts in a glucose sensor data stream

Analyte sensor

Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor.

System and methods for processing analyte sensor data

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Oakland, NJ, United States of America

James Patrick Thrower