Abbott Laboratories Corporation

Traffix Devices, Inc.

Other

Abbvie Inc.

Crown Bolt, Inc.

James P Sullivan

Jack H Kulp

Mark W Holladay

Jean-Marc Roch

Murali Gopalakrishnan

John D McKenney

Clark A Briggs

Edward B Touma

Lisa M Monteggia

Yat Sun Or

William A Carroll

Nan-Horng Lin

Michael J Dart

Irene I Drizin

Hao Bai

Keith Brian Ryther

Henry Q Zhang

Jorge D Brioni

Paul P Ehrlich

James T Wasicak

John K Lynch

Stephen P Arneric

David G Mc Kenna

Thomas Weiss

Marlon D Cowart

Philip R Kym

Teodozyj Kolasa

Michael E Kort

Michael E Brune

Gin C Hsieh

Lin Yi

Raymond Taccolini

Robert D Weaver

David G McKenna

Yiyuan Chen

Steven A Buckner

Patricia M Sremba

Gerald F Sremba

Henry C Lisenbee

JoDee Jensen Smith

Victoria E S Scott

Kristi L Anderson

Rui Tang

A machine for manufacturing parts that includes a base having therein one or more motors, an electrical power input port and a connector for connection to a general purpose programmable controller, and including a removable part holding and aligning (or presenting) fixture which can hold and rotate one or more parts to a specific location. The machine can include a tool for performing a process on a part. The machine can include a programmed general purpose controller that can control the operation of the machine during a manufacturing process.

Part orienter with removable rotating fixture

This invention discloses a method of treatment of osteoarthritis pain by administration of a histamine Hreceptor antagonist, described herein, a salt thereof, or a composition comprising such compound or salt.

Treatment of osteoarthritis pain

A variant human &#x3b1;7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human &#x3b1;7 nAChR. Nucleic acid molecules encoding the variant human &#x3b1;7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.

Variant human &#x3b1;7 acetylcholine receptor subunit, and methods of production and use thereof

The present invention is a simulated stone structure having a base with an upfacing planar surface and a continuous groove formed in the surface. A plurality of mutually interlocking wall sections are engaged with the groove to form a continuous wall extending upwardly from the planar surface. The wall sections may be U-shaped with one leg in the groove and the other in contact with the periphery of the base. The wall sections partially overlap each other. s an abutting one of the wall sections. Additional wall sections may be placed atop the first set and interlocked with them. A topper piece may be placed on the additional wall sections for securement thereof.

Closed wall structure mounted on a grooved base

The present invention provides an isolated or purified polynucleotide that encodes human endosulfine polypeptide. Isoforms of human endosulfine are also disclosed. The invention also provides methods of making recombinant human endosulfine using the polynucleotides and host cells transformed with the polynucleotides.

Human endosulfine gene

Tubular container

A variant human &agr;7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human &agr;7 nAChR. Nucleic acid molecules encoding the variant human &agr;7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.

Variant human &agr;7 acetylcholine receptor subunit, and methods of production and use thereof

Potassium channel openers

3-Pyridyl enantiomers and their use as analgesics

The following disclosure relates to a method of treating incontinence with a compound having a specific &agr;,adrenoceptor profile.

Use of &agr;1A adrenoceptor agonists with &agr;1B and &agr;1D antagonism for the treatment of stress urinary incontinence

A variant human &agr;7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human &agr;7 nAChR. Nucleic acid molecules encoding the variant human &agr;7 nAChR, receptors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.

Variant human &agr;7 acetylcholine receptor subunit, and methods of production and uses thereof

The present invention relates to a method of controlling pain in mammals, including humans, comprising administering to a mammal or patient in need of treatment thereof selected compounds of formula I: ##STR1## or a pharmaceutically acceptable salt thereof. The invention further relates to selected (R) and (S) compounds of formula I above which are useful as analgesics as well as neuronal cell death preventors and anti-inflammatories.

A safety delineator is provided having either a conical or a tubular body portion, which has an improved handle feature permitting easy and comfortable full hand gripping of the delineator. The invention additionally solves a longstanding problem common to prior art support bases for delineators and the like, by providing a convenient handle, molded integrally with the support base element, for picking up the base. The inventive handle not only provides a convenient means for grabbing the delineator, but it also provides an additional advantage with respect to conical delineators, in that it prevents them from sticking together when they are stacked. Two types of inventive support bases are disclosed. One is a base molded from a heavy solid material, such as rubber, and includes additional advantageous features such as anti-skid grippers on the bottom surface of the base element and stacking rings molded onto the upper surface of the base element for assisting in compactly stacking a plurality of bases. The second type is molded from resilient plastic, and adapted to be filled with a ballast material such as sand. This base is advantageously molded to provide a funnel structure for filling the ballast chamber, which, after the filling step is completed, is cut off. The base element edges are then sealed to permanently seal the ballast chamber. Additional features of this type of base are its dome-like configuration and the provision of corrugations on its bottom surface, both of which contribute to its crush resistance.

Safety delineators

A mounting bracket or socket for use with a flexible highway sign capable of being rolled up for storage and portability. The mounting bracket being molded from a non-rigid, elastic material that is reasonably transparent and having a socket for accommodating a frame member for the highway sign in a non-rotatable relationship. The plastic bracket including a securing platform integrally molded therewith for securing the bracket to the highway sign. A reinforcing member of substantially the same length as the mounting bracket for clamping the highway sign between the bracket and the reinforcing member. The sign engaging surfaces of the bracket and the reinforcing member each include tear resistant elements for clamping the sign to thereby transfer the sign tearing load from the fastener securing the bracket and reinforcing member to the highway sign.

Highway signs capable of being rolled up and improved mounting brackets

Growing community of inventors

Deerfield, IL, United States of America

James P Sullivan