University System of Maryland

James P Nataro

Alessio Fasano

Myron M Levine

Fernando R Noriega

Fernando Ruiz-Perez

Provided are compositions and methods for treating inflammation due to an immune response. Non-limiting example compositions include class-2 SPATE proteins that are capable of cleaving proteins involved in an inflammatory immune response in a patient. Example compositions include at least one mucin-cleaving class-2 SPATE protein. Further example compositions include protein involved in intestinal colonization (Pic). Non-limiting example methods include methods of decreasing inflammation in a patient having inflammation and methods of perturbing immune response in a patient having a disease or condition in which an active immune response is attributable to a cause of the disease or condition, by administering to the patient a composition including at least one class-2 SPATE protein capable of cleaving proteins involved in an inflammatory immune response.

Compositions and methods for treating inflammatory bowel disease and airway inflammation

Novel proteins and their corresponding nucleotide sequences in enteroaggregative(EAEC) are provided. In particular, Aap and the five gene cluster (aat) of the AA probe region of the pAA plasmid of EAEC 042 have been identified, sequenced, and further characterized. The use of these novel proteins and their corresponding nucleotide sequences for diagnosis, therapy, and prevention of EAEC infections is also provided.

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Nucleic acids encoding novel proteins in enteroaggregative escherichia coli (EAEC)

Substantially pure enterotoxins of Shigella flexneri 2a are described, along with a method for obtaining the same, antibodies having binding specificity to the enterotoxins and a method for use of the enterotoxins to develop a non-reactogenic Shigella flexneri 2a vaccine candidate.

Antibodies having binding specificity to ShET2, an enterotoxin of

Isolated DNA molecule encoding SHET1 of Shigella flexneri 2a and mutant

Isolated DNA molecule encoding ShET2 of Shigella flexneri 2a

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Catonsville, MD, United States of America

James P Nataro