Abbott Laboratories Corporation

James P Karwowski

Marianna Jackson

James B McAlpine

Jill E Hochlowski

Sunil K Kadam

Robert J Theriault

Randal H Chen

Ronald R Rasmussen

Geewananda P Gunawardana

Mark H Buytendorp

David Frost

Disclosed are novel antifungal agents having the formula: ##STR1## as well as a pharmaceutically acceptable salt, ester of prodrug thereof, wherein R is: ##STR2## --C(O)--R.sub.1 wherein R.sub.1 is alkyl, alkenyl, aryl, arylalkenyl, aryl-aryl-, arylalkoxy-aryl-, aryl-aryl-aryl-, arylkoxy-aryl-aryl-, or ##STR3## wherein R.sub.2 is alkylamino, dialkylamino, (heterocyclic)alkyl, aryl, or arylalkyl; and X is O, NH, or NR.sub.3 wherein R.sub.3 is alkyl or aryl. Also disclosed are pharmaceutical compositions comprising a compound of the invention in combination with a pharmaceutically acceptable carrier; and a process for preparing the compounds of the invention.

Antifungal corynecandin

Novel antifungal and antitumor agents having the formula ##STR1## as well as pharmaceutically acceptable salts, esters, amides and pro-drugs thereof, wherein R is selected from the group consisting of ##STR2## Also disclosed are pharmaceutical compositions comprising such compounds, and methods of treatment and processes of manufacture relating thereto.

Dorrigocin antitumor agents

Antifungal dorrigocin derivatives

New antibiotics, unphenelfamycin and phenelfamycins A-D, are produced by microorganisms belonging to the genus Streptomyces. The antibiotics have antibacterial activity against gram-positive and gram-negative anaerobic organisms and are effective in improving the feed efficiency and growth rate of livestock, including poultry.

Antibiotics unphenelfamycin and phenelfamycins A-D

Coumamidine compounds

New compounds, tiacumicins, are produced by a microorganism belonging to the genus Dactylosporangium. The compounds are effective Gram-positive antibiotics.

Tiacumicin compounds

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Mundelein, IL, United States of America

James P Karwowski