Schering Corporation

Pharmacopeia Drug Discovery, Inc.

James P Jakway

Arthur G Taveras

Younong Yu

Purakkattle J Biju

Jianhua Chao

Daniel Lundell

Jay S Fine

John J Baldwin

Ge Li

John J Piwinski

Michael P Dwyer

Pauline C Ting

Daniel M Solomon

Richard J Friary

Jianping Chao

William Kreutner

Cynthia J Aki

J Robert Merritt

Gaifa Lai

Vera A Seidl

Johan A Ferreira

Joe F Lee

Loretta A Bober

Bernd Kaiser

Richard W Bond

Minglang Wu

Laura L Rokosz

Kingsley H Nelson, Jr

Evan A Hecker

Motasim Billah

Methods of treating chemokine-mediated diseases are disclosed. The methods comprise the administration of CXC-Chemokine receptor antagonists of the formula or pharmaceutically acceptable salts or solvates thereof, in combination with other classes of pharmaceutical compounds. The chemokine-mediated diseases include acute and chronic inflammatory disorders, psoriasis, cystic fibrosis, asthma and cancer. Also disclosed are novel compounds of formula (I).

Treatment of chemokine mediated diseases

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

Disclosed are compounds of Formula I: ##STR1## or a pharmaceutically acceptable salt or solvate thereof, wherein: R.sup.3 is alkyl, alkenyl, alkynyl, aryl, alkaryl, aralkyl, cycloalkyl, acyloxymethyl, alkoxy, alkoxymethyl, or alkyl substituted with cycloalkyl; R.sup.4 is H, alkyl, alkenyl, alkoxy, or --OH. Also disclosed are pharmaceutical compositions containing compounds of Formula I, methods for inhibiting tumor necrosis factor-.alpha. and methods for treating septic shock, inflammation, or allergic disease by administering a compound of Formula I.

Tricyclic derivatives, compositions and methods of use

Growing community of inventors

Bridgewater, NJ, United States of America

James P Jakway