Ortho Pharmaceutical Corporation

Other

Burstein Technologies, Inc.

Nagaoka Co., Ltd.

Pharmocon LLC

James P Demers

Richard B Sulsky

Ramesh M Kanojia

Sigmond G Johnson

Dieter H Klaubert

Michele Ann Weidner-Wells

Stephanie A Fraga

William V Murray

Dennis J Hlasta

Donald W Combs

Darryl C Rideout

William Wei

John F O'Connell, Jr

The invention provides a system of mobile robotic devices configured to install the posts, racks, and photovoltaic (PV) panels of a solar farm. The invention also provides a computer command system (CCS) to direct the robotic devices for installation of the posts, racks, and panels with optimum speed and efficiency.

Automated solar farm construction

The invention provides buffers stable to oxidants, including chlorine and hypochlorous acid, which are usable in the pH range 3-7. The invention also provides stable, buffered solutions comprising hypochlorous acid, having a pH between 3 and 7, and disposable wiping articles impregnated with these solutions.

Materials amd methods for buffering active chlorine solutions

A method for preparing very large spatially-addressable arrays of chemical compounds by light-directed synthesis is provided, wherein the light is provided by a laser and the compounds are arrayed on a rotating disc in a CD-ROM format. A method for assaying the resulting array with a CD-ROM mechanism is also provided.

Spatially addressable combinatorial chemical arrays in encoded optical disk format

The invention relates to triphenylalkyl antibacterial compounds of the general formula: ##STR1## pharmaceutical compositions containing the compounds, and methods for their production and use. These compounds are effective in inhibiting the action of a bacterial histidine protein kinase and are thus useful as anti-infective agents against a variety of bacterial organisms, including organisms which are resistant to other known antibiotics.

Triphenylalkyl antimicrobial agents

The invention relates to diaryl antimicrobial compounds of the general formula: ##STR1## where G, E L, J, q, m, X, Ar, W, p, n and A are as described herein, pharmaceutical compositions containing the compounds, methods for their production and their use in treating bacterial infections.

Diaryl antimicrobial agents

A breakage-resistant form of separatory funnel or other laboratory glassware, such as addition funnel, flask, buret, or chromatography column, is provided. The glassware features an unbreakable plastic stem, preferably removably attached, below the glass stopcock in place of the usual glass stem.

Breakage resistant laboratory glassware article

The invention provides novel 5-hydroxy-4-aryl- and 5-hydroxy-4-(arylthio)-2(5H)-furanones of the following structure: ##STR1## wherein R contains from about five to about twenty carbon atoms and is defined herein; X is oxygen, sulfur, SO.sub.2, NH, N(lower alkyl), N(lower acyl), aminocarbonyl, carbonyl, carbonylamino, CH.sub.2 or a carbon-carbon bond; Y is hydrogen, halogen, lower alkyl, nitro, alkylthio, perfluoroalkyl, hydroxy, or lower alkoxy(C.sub.1 -C.sub.8); Z is sulfur or a carbon-carbon bond; and Q is H, an alkyl of from 1-20 carbon atoms, COR', COOR', CONHR', PO(OR')2, PO(OR')R' wherein R' and R' are independently selected from the group consisting of H, an alkyl of from 1-20 carbon atoms, phenyl, and substituted phenyl and prodrugs thereof and pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprising these compounds, methods of using these compounds as inhibitors of inflammation and for treating other diseases characterized by the overproduction of arachidonic acid metabolites, intermediates and methods of preparing these compounds are also provided.

4-aryl- and 4-arylthio-5-hydroxy-2(5H)-furanones as inhibitors of

The invention relates to a process for the synthesis of compounds of the formula I ##STR1## wherein R.sub.1 -R.sub.5 are as defined herein. The process is a multistep process which comprises acylating a 2-benzoxazolinone with an alkanoic anhydride to form an acylated carbamate, hydrolyzing the carbamate, reacting the resultant aminophenol with haloalkanoyl halide to form a substituted benzoxazine, reacting the benzoxazine with an aldehyde, alkylating the resultant aminomethyl compound with an alkylating agent to form a quaternary ammonium salt, reacting the salt with an alkali metal cyanide to form a nitrile, hydrolyzing the nitrile and reacting the resultant carboxylic acid with hydrazine. The compounds are useful as cardiotonic and vasodilating agents and as inhibitors of phosphodiesterase fraction III and platelet aggregation. In addition, the compounds are active as smooth muscle relaxants and bronchodilators.

Process for the preparation of

The present invention relates to substituted hydroxyureas. These compounds inhibit the enzyme 5-lipoxygenase. In addition, certain of the compounds also inhibit the enzyme-cyclooxygenase. The compounds are useful for treating asthma, allergies, arthritis, posoriasis, ischemia, dermatitis, inflammation and/or broncho-constriction and/or inflammatory diseases of the eye.

Substituted hydroxyureas

1H-1,2,4-thiadiazolo[3,4-b]quinazolin-5-one-2,2-dioxides are disclosed. These compounds are useful as caridotonic agents. A preferred compound is 7-(n-cyclohexyl-N-methyl-4-amino-4-oxobutyloxy)-1H-1,2,4-thiadiazolo[3,4-b ]quinazolin-5-one-2,2-dioxide.

1H-1,2,4-thiadiazolo(3,4-b)quinazolin-5-one-2,2-dioxides, and a method

A process for the preparation of aryl hydrazines and indazoles by reacting organometallic regents with azodicarboxylates.

Process for the preparation of indazoles

The present invention relates to cinnamohydroxamic acids. These compounds inhibit 5-lipoxygenase and are useful as bronchodilators.

Growing community of inventors

New York, NY, United States of America

James P Demers