Covidien LP

Nellcor Puritan Bennett Ireland

Other

Nellcor Puritan Bennett Incorporated

James Ochs

Paul Stanley Addison

James Nicholas Watson

Scott A Amundson

Keith Batchelder

Scott McGonigle

James Dripps

Paul David Mannheimer

Edward M McKenna

Li Li

Binwei Weng

Clark Raymond Baker, Jr

Ron Kadlec

Bo Chen

Paul Francis Stetson

Hui Wang

Niranjan Maharajh

Michael Mestek

Robin Boyce

Mark Kolnsberg

Corinne H Johnson

Jimmy Dripps

Steven Vargas

Tonia Madere

Yu-Jung Pinto

Binwel Weng

Scott Mcgonigle

James Watson

Embodiments of the present disclosure provide systems and methods for monitoring a patient to produce a signal representing a blood oxygen concentration. The signal may be analyzed to determine the presence of one or more sleep apnea events, and an integral of the signal may be calculated if the signal is outside of a set range or threshold. A practitioner may choose to be informed of the presence of sleep apnea events if the blood oxygen concentration is less then a preset limit, if an upper limit has been reached for an integral representing the severity of the oxygen deprivation over time, or anytime sleep apnea events may be present in the signal.

Methods and systems for alerting practitioners to physiological conditions

Systems and methods are provided for determining respiration information from physiological signals such as PPG signals. A physiological signal is processed to generate at least one respiration information signal and an autocorrelation sequence is generated based on the at least one respiration information signal. In some embodiments, a respiration peak is identified based on the autocorrelation sequence and a composite peak is generated based on the identified peak and at least one previous respiration peak. Respiration information is calculated based on the composite peak. In some embodiments, a determination is made whether the autocorrelation sequence includes an undesired harmonic. When the autocorrelation sequence includes an undesired harmonic, the autocorrelation sequence may not be used in the calculation of respiration information.

Systems and methods for filtering autocorrelation peaks and detecting harmonics

A patient monitoring system may receive a physiological signal such as a photoplethysmograph (PPG) signal that exhibits frequency and amplitude modulation based on respiration. A phase locked loop may generate a frequency demodulated signal and an amplitude demodulated signal from the PPG signal. An autocorrelation sequence may be generated for each of the frequency demodulated signal and the amplitude demodulated signal. The autocorrelation sequences may be combined and respiration information may be determined based on the combined autocorrelation sequence.

Systems and methods for determining respiration information using phase locked loop

Systems and methods are provided for detecting held breath events. A physiological signal, such as a photoplethysmograph (PPG) signal, is processed to extract respiration-related morphology metric signals. The morphology signals are analyzed to determine when a patient's breath is being held.

Systems and methods for detecting held breath events

Methods and systems are presented for determining regional blood oxygen saturation (rSO) of a subject. Differential absorption values may be determined based on received first and second light signals corresponding to light attenuated by respective first and second regions of the subject. Reference absorption curves are received, each associated with an rSOvalue and containing expected absorption values. The differential absorption values are compared with the expected absorption values to determine a best fit reference absorption curve. An rSOvalue is determined based on the best fit reference absorption curve. An rSOvalue may also be determined based on a combination of two or more rSOestimates. The rSOestimates are determined based on two or more pairs of the differential absorption values. The differential absorption values are determined based on received first and second lights signals corresponding to three or more wavelengths of light.

Methods and systems for determining regional blood oxygen saturation

An apnea analysis system may include a photoplethysmographic (PPG) sub-system, a breath detection sub-system, and an apnea analysis module. An apnea analysis system includes a photoplethysmographic (PPG) sub-system, a breath detection sub-system, and an apnea analysis module. The PPG sub-system is configured to be operatively connected to an individual and output a PPG signal from the individual. The breath detection sub-system is configured to be operatively connected to the individual and output a breath signal from the individual. The apnea analysis module is in communication with the PPG sub-system and the breath detection sub-system. The apnea analysis module analyzes the breath signal and a respiratory component of the PPG signal and, based on the analysis, identifies a presence of apnea, differentiates between obstructive apnea and central apnea, and provides an indication of the identified apnea.

Apnea analysis system and method

A signal representing physiological information may include information related to respiration. A patient monitoring system may generate a plurality of autocorrelation sequences from the signal and combine the autocorrelation sequences to generate a combined autocorrelation sequence. The combined autocorrelation sequence may be analyzed to identify one or more peaks that may correspond to respiration information. Respiration information such as respiration rate may be determined based on the one or more peaks.

Systems and methods for determining respiration information from a photoplethysmograph

A patient monitoring system may generate an autocorrelation sequence for a physiological signal such as a photoplethysmograph signal. A series of peak values may be identified for the autocorrelation sequence. The peak values may be modified based on a historical distribution of a physiological parameter. A physiological parameter such as respiration rate may be determined based on the modified peak values.

Systems and methods for determining respiration information using historical distribution

A patient monitoring system may generate a derivative signal from a physiological signal. The derivative signal may be filtered based on a pulse rate estimate associated with the physiological signal. A plurality of crossing points may be determined for the filtered derivative signal and translated to the derivative signal. A plurality of fiducial points may be determined for the derivative signal based on the plurality of crossing points. The plurality of fiducial points may be utilized to determine physiological information from the physiological signal.

Systems and methods for determining physiological information by identifying fiducial points in a physiological signal

A patient monitoring system may receive a photoplethysmograph (PPG) signal including samples of a pulse waveform. The PPG signal may demonstrate morphology changes based on respiration. The system may calculate morphology metrics from the PPG signal, the first derivative of the PPG signal, the second derivative of the PPG signal, or any combination thereof. The morphology metrics may demonstrate amplitude modulation, baseline modulation, and frequency modulation of the PPG signal that is related to respiration. Morphology metric signals generated from the morphology metrics may be used to determine respiration information such as respiration rate.

Methods and systems are discussed for determining venous oxygen saturation by calculating a ratio of ratios from respiration-induced baseline modulations. A calculated venous ratio of ratios may be compared with a look-up table value to estimate venous oxygen saturation. A calculated venous ratio of ratios is compared with an arterial ratio of ratios to determine whether baseline modulations are the result of a subject's respiration or movement. Such a determination is also made by deriving a venous ratio of ratios using a transform technique, such as a continuous wavelet transform. Derived venous and arterial saturation values are used to non-invasively determine a cardiac output of the subject.

Venous oxygen saturation systems and methods

A signal representing physiological information may include information related to respiration. A patient monitoring system may utilize a wavelet transform to generate a scalogram from the signal. A threshold for the scalogram may be calculated, and scalogram values may be compared to the threshold. One of the scales meeting the threshold may be selected as representing respiration information such as respiration rate. The respiration information may be determined based on the selected scale.

The present disclosure relates generally to patient monitoring systems and, more particularly, to signal analysis for patient monitoring systems. In one embodiment, a method of analyzing a detector signal of a physiological patient sensor includes obtaining the detector signal from the physiological patient sensor, and determining a ratio of the signal between two or more channels. A distribution of the angles between the points of the ratio over time may be used to determine a true ratio or a ratio of ratios for use in the determination of a physiological parameter.

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Seattle, WA, United States of America

James Ochs