Harvard College

The General Hospital Corporation

University of Massachusetts

James Niemi

Hani Sallum

Premananda Pai Indic

John Paul Osborne

Donald Elliot Ingber

Andy H Levine

James Joseph Collins

Arun Dhyaneshwar Chawan

Robert J Wood

Riccardo Barbieri

Amanda Wozniak

David Paydarfar

Olivier F Henry

Christoph Matthias Kanzler

Daniel Leo Miranda

Joseph Mooney

Huy Lam

Mustafa Karabas

Alan Dunne

Benjamin Matthews

Ruby Kandah

Hani M Sallum

A wearable system is directed to neurological stimulation of a human foot, and includes a controller with at least one bias signal generator for outputting a driving signal. The system further includes a power source that provides electrical energy to the controller, including providing electrical energy to the bias signal generator. The system also includes a platform in the form of an insole insert of a shoe, the insole insert having a plurality of actuators positioned in a medial arch region of the foot. The plurality of actuators stimulate the medial arch region in response to receiving the driving signal from the controller. The stimulation of the plurality of actuators provides a subthreshold bias signal to target cells with a subthreshold bias signal magnitude that is below a threshold where the target cells are activated by a stimulus. The plurality of actuators is surrounded with a vibration dissipating material.

Insole design and actuator placement for balance and gait

Systems and methods are disclosed to monitor physiological for the occurrence of life threatening events and to apply stimulation to prevent the occurrence of said life-threatening events. Systems and methods for applying the stimulation are also disclosed. These systems include applying the stimulation through via a mattress having a passive section and an active section, a plurality of focal stimulators, and/or an array to apply the stimulation are also disclosed. These devices include a mattress with an active region and a passive region, a stimulating array do deliver targeted stimulation, and a plurality of stimulators to apply focused stimulation.

Systems and methods for inhibiting apneic events

A physiologic sensor module includes at least one wearable sensor that is configured for wearing on a human body part and for measuring at least one biological signal. The module further includes at least one controller communicatively coupled to the wearable sensor and configured to receive the biological signal from the wearable sensor. The controller is further configured to process the biological signal in real-time, extract one or more clinical features from the biological signal, and based on the clinical features, determine detection of anaphylaxis.

Systems and methods for monitoring, managing, and treating asthma and anaphylaxis

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Concord, MA, United States of America

James Niemi