Bristol-myers Squibb Compnay

James Neels

Heather J Finlay

John E Lloyd

James A Johnson

Naveen Kumar Dhondi

Prashantha Gunaga

Abhisek Banerjee

Ashokkumar Adisechan

Ji Jiang

Jennifer X Qiao

Zulan Pi

Carol Hui Hu

Michael A Poss

Douglas G Batt

Joseph Anthony Tino

Robert J Cherney

Scott Hunter Watterson

Rajeev S Bhide

Tammy C Wang

Jon J Hangeland

George O Tora

Qingjie Liu

Todd J Friends

David Marcoux

Zheming Ruan

Lyndon A M Cornelius

Anurag S Srivastava

Qing Shi

Lan-Ying Qin

Ashok Kumar Adisechan

Lyndon AM Cornelius

A compound of formula I wherein A, X, Y, Z, Rand Rare described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, I-associated disorders, and other disorders mediated by ion channel function.

Quinazolines as potassium ion channel inhibitors

Disclosed are compounds of Formula (I) or a salt thereof; wherein: X is N or CH; Qis: (i) Cl, Br, I, &#x2014;CN, &#x2014;CH, or &#x2014;CF; (ii) a 5-membered heteroaryl selected from pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, triazolyl, oxadiazolyl, and thiadiazolyl; (iii) a 6?membered heteroaryl selected from pyridinyl, pyridazinyl, and pyrimidinyl; or (iv) a bicyclic heteroaryl selected from indolyl, pyrrolopyridinyl, pyrazolopyridinyl and benzo[d]oxazolyl; wherein each of said 5-membered, 6-membered, and bicyclic heteroaryl is substituted with zero to 1 Rand zero to 1 R; and R, R, R, R, R, R, R, and Rare defined herein. Also disclosed are methods of using such compounds as modulators of PI3K, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases. 

Bicyclic heteroaryl amine compounds

The present invention provides compounds of Formula (I): (I), as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments. 

Pyrrolinone carboxamide compounds useful as endothelial lipase inhibitors

The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments. 

Pyridinedione carboxamide inhibitors of endothelial lipase

A compound of formula (I) wherein A, X, Y, Z, Rand Rare described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, I-associated disorders, and other disorders mediated by ion channel function. 

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Newtown, PA, United States of America

James Neels