Gilead Sciences, Inc.

American Cyanamid Company

Wyeth Holdings Corporation

Wyeth

Immunex Corporation

Max-planck-institute for Biochemistry

James Ming Chen

Jeremy Ian Levin

Xiaowu Chen

Maria Fardis

William John Watkins

Aesop Cho

Thorsten A Kirschberg

Lee Shun Chong

Sundaramoorthi Swaminathan

Carina E Cannizzaro

Richard L Mackman

Hyung-Jung Pyun

Choung U Kim

Jennifer R Zhang

Adrian S Ray

Alan X Huang

Christopher P Lee

David A Oare

Arie Zask

Constantine G Boojamra

William A Lee

Haolun Jin

David Y Markevitch

Vidya K Prasad

Ralph F Hirschmann

Manoj C Desai

Peter H Nelson

Derek Cecil Cole

Mila T Du

Aranapakam Mudumbai Venkatesan

Kuei-Ying Lin

Frances Christy Nelson

Rosemarie Sherlock

Dominick Mobilio

Lianhong Xu

Lijun Zhang

Steven H Krawczyk

Ramaswamy Nilakantan

Leif M Laakso

Jay Donald Albright

Michael L Mitchell

Vincent Premaratna Sandanayaka

Oliver L Saunders

George Theodore Grosu

Jason K Perry

Jamie Marie Davis

Jannie Lea Baker

Craig S Gibbs

Rosemarie O'Shea

Matthew A Williams

Zheng-Yu Yang

Jay P Parrish

Hongtao Liu

Efren Guillermo Delos Santos

David Sperandio

Raymond J Paxton

Roy A Black

Murty N Arimilli

Gong-Xin He

Wolfram Bode

Kevin Delos Parris

Robert L Powers

Jianying Wang

Zhang Bao Xu

Jiancun Zhang

Sundaramoorthi Swaninathan

James D Tario

Laura N Schacherer

Xue-Mei Du

Franklin J Moy

Klaus Maskos

Carlos Fernandez-Catalan

Mark M Becker

Clifford Bryant

Azar Dastgah

Tanisha D Rowe

Mark Sparacino

Richard H Yu

Will Watkins

The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Antiviral phosphonate analogs

The invention provides unsaturated phosphonates of Formula I or a tautomer or pharmaceutically acceptable salt thereof, as described herein, as well as pharmaceutical compositions comprising the compounds, and therapeutic methods comprising administering the compounds. The compounds have anti-viral properties and are useful for treating viral infections (e.g. HCV) in animals (e.g. humans). 

Nucleoside analogs for antiviral treatment

A compound of Formula I, Formula II, Formula III, or Formula IV: or a pharmaceutically acceptable salt, solvate, and/or ester thereof, therapeutic compositions containing such compounds, and therapeutic methods that include the administration of such compounds.

Phosphonate inhibitors of HCV

The invention is related to compounds of Formula I: or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.

AZA-peptide protease inhibitors

Antiviral protease inhibitors

The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents.

Therapeutic phosphonate compounds

The invention is related to phosphonate substituted compounds having immuno-modulatory activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Phosphonate compounds having immuno-modulatory activity

Ortho-sulfonamido aryl hydroxamic acids are provided which are useful, inter alia, for the inhibition of matrix metalloproteinases and the treatment of conditions associated with overexpression of MMPs.

Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase inhibitors

Phosphorus-substituted imidazole compounds with anti-HIV properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit reverse transcriptase activity and are useful therapeutically for the inhibition of such enzymes, as well as in assays for the detection of such enzymes.

Non nucleoside reverse transcriptase inhibitors

The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Anti-cancer phosphonate analogs

The invention is related to phosphorus substituted anti-inflammatory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Anti-inflammatory phosphonate compounds

The invention is related to phosphorus substituted IMPDH inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Inosine monophosphate dehydrogenase inhibitory phosphonate compounds

Growing community of inventors

San Ramon, CA, United States of America

James Ming Chen