Illumina Corporation

Illumina Singapore Pte. Ltd.

Other

James Michael Osmus

Philip Y Paik

Jay Taylor

Lea Kobeli

Erik Allegoren

Jack Godfrey Wood

Edward Wilson Licitra

Michael Thomas Dangelo

James Christopher Blake

Richard L Lemoine

Carlos Dominguez

Bradley Kent Drews

Jack Godfrey-Wood

Dale Buermann

Wenyi Feng

Scott Michael Janis

Max Warren Pollock

Alexander Triener

Erik D Olson

Sz-Chin Steven Lin

Paul Crivelli

Beng Keong Ang

Steven Scott Phelps

Stephen Wayne Clark

Anna Skaro Quackenbush

Bashkaran Subramanian

Michael Adalbert Niziolek

Umberto Ulmanella

Michael Dai Wang

Johanna Lynn Whitacre

Michelle L Alvarez

Debra Sue Bryan

Joshua Augustin Darland

Tsukasa Takahashi

Brandon Westerberg

Jian Gong

David Elliott Kaplan

Ashish Kumar

Robert Nicholas Dean

Wesley A Cox-Muranami

Wesley A Cox-muranami

Richard Lemoine

An analysis instrument may perform analytical operations on an analyte that is combined with multiple reagents prior to being introduced into a flow cell. The instrument may include a nozzle sipper that aspirates reagents from a recipient, along with an analyte. The reagents may be directed to a volume and may be repeatedly moved into and out of the volume by cycling of a pump. The reagents may be ejected into a destination recipient with the nozzle sipper promoting vorticity in the recipient to enhance mixing. The repeated aspiration and ejection through the nozzle sipper effectively mixes the reagents and the template in an automated or semi-automated fashion.

Reagent nozzle sipper mixing system and method

Sequencing instrument

An apparatus includes a fluidic circuit, a bypass fluidic circuit, a first set of fluid wells, a second set of fluid wells, a first valve, and a second valve. The first valve operatively associated with the first set of fluid wells such that the first selectively fluidly connects any one of the first set of fluid wells to a first valve outlet. The second valve operatively associated with the fluidic circuit, the bypass fluidic circuit, the first valve outlet, and the second set of fluid wells such that the second valve selectively fluidly connects any one of the second set of fluid wells and the first valve outlet to the fluidic circuit or the first valve outlet to the bypass fluidic circuit.

Multi-valve fluid cartridge

Gasket assemblies and related system and methods. An apparatus includes a system, a flow cell, and a plurality of gasket assemblies. The system includes a flow cell interface and the flow cell has one or more channels. Each channel has a first channel opening and a second channel opening. The first channel openings are positioned at a first end of the flow cell and the second channel openings are positioned at a second end of the flow cell. A gasket assembly coupled at each second channel opening. Each gasket assembly includes an adhesive stack and a gasket. The adhesive stack includes a first side bonded to the gasket and a second side bonded to the flow cell. The flow cell interface is engagable with the corresponding gaskets to establish a fluidic coupling between system and the flow cell.

Flow cell assemblies and related systems

Flow cell cartridge

Flow cell device

Cartridge cover

Cartridge chassis

A cartridge assembly comprises a housing having an illumination chamber and a well plate. The well plate is maintained within the housing and has liquid wells to receive desired amounts of liquids. The well plate includes a fluidics analysis station aligned with the illumination chamber, and an interface window and interface ports located at the fluidics analysis station. The well plate includes a valve station and pump station. A piercer unit is provided in the housing and positioned proximate to the wells. The piercer unit includes a piercer element and is to be moved to a piercing position where the piercer element pierces a cover for the corresponding well. A pump assembly on the well plate at the pump station manages fluid flow through the channels between the pump station and the fluidics analysis station. The housing includes a flow cell chamber to receive a removable flow cell cartridge.

Cartridge assembly

Sequencing cartridge assembly

Growing community of inventors

San Diego, CA, United States of America

James Michael Osmus