Merck Sharp + Dohme Corp.

James Michael Crawforth

Andrew Pate Owens

Timothy Harrison

Michael Rowley

Martin Richard Teall

David James Hallett

Jason Matthew Elliott

Francine Sternfeld

Simon Charles Goodacre

The invention provides compounds of formula I: which are inhibitors of &#x3b3;-secretase and hence useful in the treatment or prevention of Alzheimer's disease.

Sulphones for inhibition of gamma secretase

A class of 3-phenylimidazo[1,2-a]pyridine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group which is directly attached or bridged by an oxygen atom or a &#x2014;NH-linkage, are selective ligands for GABAreceptors, in particular having high affinity for the &#x3b1;2 and/or &#x3b1;3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.

Imidazo-pyridine derivatives as ligands for GABA receptors

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Watton-at-Stone, United Kingdom

James Michael Crawforth