Abs Global, Inc.

James Maxwell Schiller

Frederick Hershel Savage

Zheng Xia

David Appleyard

Daniel McAda

John Walker Rupel, Ii

Timothy Miller

Alec Fisher

Disclosed is an approach to differentiating between different particle types in samples flowing through microfluidics chips. A sample may have an initial proportion of a first cell type to a second cell type. An illuminating light source may emit a coherent light at the sample, and light leaving the chip in a first direction may be detected using a first light detector, and light leaving the chip in a second direction (e.g., orthogonal to the first direction) may be detected using a second light detector. The detected light may be fluorescence. An orientational feature of a plurality of cells in the sample may be determined based on the light detected by the detectors. Based on the orientational features and the detected light, a biasing operation may be performed for each cell in the sample to obtain a modified proportion of cell types in the sample.

Cell differentiation based on multi-directional light from a microfluidic chip

Growing community of inventors

Madison, WI, United States of America

James Maxwell Schiller