Seattle Children's Hospital

Purdue Research Foundation

Endocyte, Inc.

James Matthaei

Michael C Jensen

Philip Stewart Low

Christopher Paul Leamon

Yingjuan June Lu

Haiyan Chu

Leroy W Wheeler, Ii

Navin Robert Charles Pinto

Julie Ruggieri Park

Richard Messmann

Aspects described herein pertain to engineered chimeric antigen receptors (CARs) and compositions thereof having specificity and affinity for fluorescein containing ligands presented on the surface of tumor cells. Also provided herein are compositions including CARs further comprising a spacer arm and methods of making and using these compositions.

Fluorescein-specific cars exhibiting optimal t cell function against FL-PLE labelled tumors

The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells wherein the CAR T cells comprise a CAR and the CAR comprises an E2 anti-fluorescein antibody fragment, and administering to the patient a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.

Methods of use for CAR T cells

The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and administering to the patient a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.

Sequencing method for CAR T cell therapy

Aspects of the invention described herein relate to synthetic compounds that are useful for targeting and labeling tumor cells so as to facilitate recognition by binding agents including Chimeric Antigen Receptor T cells (CAR T cells), which are administered to a subject by intravenous or locoregional administration. Several compositions and methods of making and using these compositions to treat or inhibit a disease in a subject are contemplated.

Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents

Growing community of inventors

Seattle, WA, United States of America

James Matthaei