Edwards Lifesciences Corporation

Abl IP Holding LLC

Fusion Optix, Inc.

James M Young

Louis A Campbell

Ralph Schneider

John F Migliazza

Jeffrey S Dove

Gregory A Wright

Bin Tian

Ivan Jankovic

Jeffrey S Cohen

Jeff Cohen

Zane Arthur Coleman

Frank A Friedman

John X Zhang

Zane Coleman

Peter Yi Yan Ngai

Peter Yi Ngai

Frank Friedman

Methods for the conditioning of bioprosthetic material employ bovine pericardial membrane. A laser directed at the fibrous surface of the membrane and moved relative thereto reduces the thickness of the membrane to a specific uniform thickness and smoothes the surface. The wavelength, power and pulse rate of the laser are selected which will smooth the fibrous surface as well as ablate the surface to the appropriate thickness. Alternatively, a dermatome is used to remove a layer of material from the fibrous surface of the membrane. Thinning may also employ compression. Stepwise compression with cross-linking to stabilize the membrane is used to avoid damaging the membrane through inelastic compression. Rather, the membrane is bound in the elastic compressed state through addition cross-linking. The foregoing several thinning techniques may be employed together to achieve strong thin membranes.

Methods of conditioning sheet bioprosthetic tissue

Methods for the conditioning of bioprosthetic material employ bovine pericardial membrane. A laser directed at the fibrous surface of the membrane and moved relative thereto reduces the thickness of the membrane to a specific uniform thickness and smoothes the surface. The wavelength, power and pulse rate of the laser are selected which will smooth the fibrous surface as well as ablate the surface to the appropriate thickness. Alternatively, a dermatome is used to remove a layer of material from the fibrous surface of the membrane. Thinning may also employ compression. Stepwise compression with cross-linking to stabilize the membrane is used to avoid damaging the membrane through inelastic compression. Rather, the membrane is bound in the elastic compressed state through addition cross-linking. The foregoing several thinning techniques may be employed together to achieve strong thin membranes. The finally thinned membrane may then be treated by capping of calcification nucleation sites and borohydride reduction. The leaflets may be formed to have more than one region of uniform thickness, such as a thicker peripheral sewing region.

In one aspect, the present invention provides light emitting devices, including light fixtures and luminaires. In some embodiments, a light emitting device comprises at least one light source, a lightguide operable to receive light from the at least one light source at a first location on the lightguide, at least one light extraction region optically coupled to the lightguide and a substantially non-scattering region along a portion of the lightguide.

Light emitting devices and applications thereof

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Ladera Ranch, CA, United States of America

James M Young