Lumen Bioscience, Inc.

Fred Hutchinson Cancer Center

Other

Matrix Genetics, LLC

Targeted Growth, Inc.

Reliance Holding Usa, Inc.

Sloan-kettering Institute for Cancer Research

Lumen Biosciences, Inc.

Matrix Genetrics, LLC

James M Roberts

Andrew C Koff

Jason W Hickman

Ryo Takeuchi

Fred Cross

Damian Carrieri

Joan Massague

Paul Warrener

Ernesto Javier Munoz

Motoaki Ohtsubo

Michael Carleton

Kornelia Polyak

Frederick Cross

Kimberly Marie Kotovic

Martin Henry Lee

Khadidja Romari

Paul A Olivier

Jay Derocher

Steven R Coats

Matthew L Fero

Margaret Mary McCormick

Mark Heinnickel

Barry L Stoddard

Phoebe Roberts

Tracy Saveria

Michael A Tasch

Nisar P Malek

Beth L Kelly

Brett K Kaiser

Peggy L Porter

Rose H Roberts

David M Doughty

Nhi Khuong

Rolf Kuestner

The present disclosure provides oral antigenic compositions comprising a recombinantcomprising at least one exogenous antigenic epitope. Oral antigenic compositions of the present disclosure can be used as vaccines. Oral antigenic compositions of the present disclosure can be used to induce a protective immune response to infectious microorganism, tumor antigens, or self-antigens.

Arthrospira platensis oral vaccine delivery platform

Provided herein are novel thermostable phycobiliproteins. These proteins may be stabilized by the introduction of disulfide bonds which stabilize the protein. Modified cells expressing these thermostable phycobiliproteins and methods of making them are also provided.

Thermostable phycobiliproteins produced from recombinant arthrospira

This disclosure describes techniques for creating stable, targeted mutations in() andhaving stable, targeted mutations.

Targeted mutagenesis in spirulina

This disclosure describes modified photosynthetic microorganisms, including Cyanobacteria, that have a reduced amount of a light harvesting protein (LHP) and contain one or more introduced or overexpressed polynucleotides encoding one or more enzymes associated with lipid biosynthesis, and which are capable of producing increased amounts of fatty acids and/or synthesizing triglycerides.

Cyanobacteria having improved photosynthetic activity

Microorganisms with increased photosynthetic capacity are described. Increased photosynthetic capacity is achieved by down-regulating activity of the RpaB pathway. The microorganisms include Cyanobacteria, including genetically-modified Cyanobacteria.

Microorganisms with increased photosynthetic capacity

Photosynthetic microorganisms with broadened light absorption capability and increased photosynthetic activity are described. Broadened light absorption is achieved by modifying the microorganism to utilize non-native bilins. Increased photosynthetic activity results from the broadened light absorption and can also result from a decrease in self-shading. The microorganisms include Cyanobacteria, including modified Cyanobacteria.

Microorganisms with broadened light absorption capability and increased photosynthetic activity

This disclosure describes modified photosynthetic microorganisms, including Cyanobacteria that have a reduced amount of a light harvesting protein (LHP) and contain one or more introduced or overexpressed polynucleotides encoding one or more enzymes associated with lipid biosynthesis, and which are capable of producing increased amounts of fatty acids and/or synthesizing triglycerides.

Targeted mutagenesis in

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Disclosed are mutant CDK inhibitor (CKI) polypeptides having dominant negative antagonist activity against wild-type CKI proteins, as well as related compositions, including nucleic acids and vectors encoding the mutant CKI polypeptides and transformed host cells and transgenic plants comprising such nucleic acids and vectors. Also disclosed are related methods for using the mutant proteins to modulate cell division in cells, particularly plant cells.

Dominant negative mutant KRP protein protection of active cyclin-CDK complex inhibition by wild-type KRP

Growing community of inventors

Seattle, WA, United States of America

James M Roberts