American Cyanamid Company

James M Quinlan

Larry Dean Spicer

Irwin B Wood

David Farley Johnson

Harold Berger

There are provided non-aqueous pour-on, water-fast formulations effective for the control of internal and external parasitic infections and infestations of homothermic animals such as mammalian quadrupeds. The pour-on formulations of the present invention contain as the active ingredient, a compound selected from the group consisting of LL-F28249&agr;-&lgr;, 23-oxo (keto) and 23-imino derivatives of the compounds collectively defined as LL-F28249, and milbemycin and avermectin molecules.

Pour-on formulations effective for the control of internal and external parasites of homothermic animals

The present invention provides nonaqueous compositions comprising a saccharide fatty acid ester and an active compound. The nonaqueous compositions of this invention may be parenterally administered to animals and humans. In particular, the nonaqueous compositions of the present invention are useful for preventing, controlling or treating helminth, acarid or arthropod endo- or ectoparasitic infection or infestation in warm-blooded animals.

Nonaqueous compositions for parenteral administration

The invention provides physically stable anthelmintic paste compositions containing resinates of d1-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole and other anthelmintic compounds in combination with a wide variety of therapeutic agents such as antibiotics, vitamins, vaccines, or mineral supplements.

Anthelmintic paste compositions containing resinates of

There are provided palatable anthelmintic resinate compositions for companion animals, containing anthelmintically effective amounts of a styrylpyridinium compound and/or an N,N-dialkylpiperazine carboxamide.

Diethylcarbamazine resinate and styrylpyridinium

This invention relates to aqueous gels, which remain gelatinous in a temperature range as low as -27.degree. C. containing dl- or 1-6-phenyl-2,3,5,6-tetrahydro(-)imidazo[2,1-b]thiazole, acylamino derivatives, thereof and pharmaceutically acceptable salts thereof, characterized by gelation and preparation at ambient temperatures (20.degree.-60.degree. C.), under vacuum, without additional heating or cooling in their preparation.

Anthelmintic gel composition and a method for their preparation at

There are provided a palatable anthelmintic resinate composition having improved storage and handling characteristics comprising from 2% to 5% of a resinate N,N-dialkylpiperazine carboxamide, from 0% to 7% of a resinated styryl pyridinium compound, from 18% to 60% of dessicated liver, from 20 to 47% of dry whey, and from 1% to 10% of polyvinylpyriolidone, carboxypolymethylene or mixtures thereof, said percentages being all by weight, and a method for preparing the same.

Diethylcarbamazine resinate and styrlpyridinium

There are provided levamisole effervescent tablets which comprise a composition characterized by excellent solubility yielding crystal clear solutions in water, good storage stablity, and ease of use. There are also provided methods for the oral administration of levamisole to swine in predetermined dosages via the drinking water offered to said animals utilizing the aforesaid levamisole effervescent tablets.

Levamisole effervescent tablets

There is provided a method for the control of helminths infecting homothermic domestic and farm animals wherein there is introduced into said animals' circulatory system an anthelmintically effective amount of a racemic mixture of either a substituted 6-(m-aminophenyl)-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole or an optically active levorotatory (1) isomer thereof by percutaneous absorption.

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Trenton, NJ, United States of America

James M Quinlan