Genentech, Inc.

Genetech, Inc.

Foundation Medicine, Inc.

James M Lee

William I Wood

William E Holmes

Axel Ullrich

Anan Chuntharapai

Caroline Alice Hebert

K Jin Kim

David V Goeddel

Brian Drake Bennett

William Matthews

Siao Ping Tsai

Austin L Gurney

Yan Wu

Philip E Hass

Thomas J Lee

David Hugh Stokoe

Arjun Singh

Christiaan Nicolaas Klijn

David P Arnott

Hugh J Kirkpatrick

Leonard David Goldstein

Juliann Chmielecki

Ryan J Hartmaier

Robert Gentleman

Florian Gnad

The invention provides methods of identifying a subject having cancer, such as lung cancer, by analyzing expression levels of one or more NRF2 splice variants or NRF2 target genes. The invention also provides methods of treating cancer in a subject with a NRF2 pathway antagonist, wherein the subject expresses one or more NRF2 splice variants or overexpresses one or more NRF2 target genes.

Methods for diagnosing and treating cancer by means of the expression status and mutational status of NRF2 and downstream target genes of said gene

The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

Antibodies directed to IL-17A/IL-17F heterodimers

A human VEGF-related protein (VRP) has been identified and isolated that binds to, and stimulates the phosphorylation of, the receptor tyrosine kinase Flt4. The VRP is postulated to be a third member of the VEGF protein family. Also provided are antibodies that bind to VRP and neutralize a biological activity of VRP, compositions containing the VRP or antibody, methods of use, chimeric polypeptides, and a signal polypeptide for VRP.

VEGF-related protein

Human insulin-like growth factor is synthesized in recombinant cell culture by host cells transformed with expression vectors bearing DNA encoding human insulin-like growth factor.

Preparation of human IGF via recombinant DNA technology

Agonist antibodies are disclosed which bind to the extracellular domain of receptor protein tyrosine kinases pTKs, and thereby cause dimerization and activation of the intracellular tyrosine kinase domain thereof. The antibodies are useful for activating their respective receptor and thereby enabling the role of the tyrosine kinase receptor in cell growth and/or differentiation to be studied. Chimeric proteins comprising the extracellular domain of the receptor pTKs and an immunoglobulin constant domain sequence are also disclosed.

SAL-S1 receptor protein tyrosine kinase agonist antibodies

Methods of using VEGF-related protein

Human insulin-like growth factors is synthesized in recombinant cell culture by host cells transformed with expression vectors bearing DNA encoding human insulin-like growth factors.

Protein tyrosine kinase agonist antibodies

cDNAs encoding a class of receptors, including the IL-8 receptors, have been identified in human tissue. Recombinantly produced PF4ARs are used in the preparation and purification of antibodies capable of binding to the receptors, and in diagnostic assays. The antibodies are advantageously used in the prevention and treatment of inflammatory conditions.

PF4A receptor

cDNAs encoding a class of receptors, including the IL-8 receptors, have been identified in human tissue. Recombinantly produced PF4ARs are used in the preparation and purification of antibodies capable of binding to the receptors, and in diagnostic assays. The antibodies are advantageously used in the prevention and treatment of inflammatory conditions. The cDNAs are also used to detect nucleic acids in samples. The cDNAs are also used to detect nucleic acids in samples.

Method for detection of PF4A receptor nucleic acid

Nucleic acid encoding PF4A receptor

Antibodies to PF4A receptor

Growing community of inventors

San Bruno, CA, United States of America

James M Lee