Roche Palo Alto LLC

James M Kress

Ralph New Harris, Iii

David Bruce Repke

Russell Stephen Stabler

Robert J Greenhouse

Saul Jaime-Figueroa

Nancy Elisabeth Krauss

Compounds of the formula I: or pharmaceutically acceptable salts thereof,wherein m, p, q, Ar, Rand Rare as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula I.

Tetralin and indane derivatives and uses thereof

Compounds of the formula I, II or III: or pharmaceutically acceptable salts thereof,wherein m, n, q, Ar, R, R, R, Rand Rare as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formulas I-III.

Compounds of the formula I: or pharmaceutically acceptable salts thereof,

Arylsulfonamidyl tetralin derivatives and uses thereof

Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, Rand Rare as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula I.

Compounds of Formula 1 and pharmaceutically acceptable salts thereof, wherein m, Ar, R, R, and Rare as defined herein. The invention also provides methods for preparing, coompositions comprising, and methods for using compounds of Formula 1 for treatment of central nervous system disorders.

Aryloxy quinolines and uses thereof

Compounds of the Formula I: wherein m, n, k, A, X, Y, Z, Ar, R, R, R, and Rare as defined herein. The compounds are useful as 5-HT6 receptor antagonists. Also provided are compositions comprising, methods of using, and methods of making the subject compounds.

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Sanford, NC, United States of America

James M Kress