Life Technologies Corporation

University of Houston System

Visigen Biotechnologies, Inc.

Other

James M Briggs

Richard Coale Willson

Xiaolian Gao

Susan H Hardin

Shiao-Chun Tu

Robert J Schwartz

Tommie Lloyd Lincecum

Hua Zhang

Scott R Gilbertson

Steven Bark

Harold L Kohn

Myoung Goo Kim

Robert Fox

Richard S Mursinna

John W Craft

Keun Woo Lee

Amy M Williams

Kevin MacKenzie

Yuxin Zhai

Kurt L Krause

Reza Abbasgholizadeh

Michael Benedik

Ulrich Strych

Russell W Etter

Susan A Martinis

The present disclosure describes peptide inhibitors of Rho-associtated-kinase (ROCK) and their use in treating disorders including heart failure, the leading cause of combined morbidity and mortality in the United States. An inhibitory polypeptide blocks ROCK1 activity in the presence of 1 mM ATP. The binding epitope on ROCK1 was mapped using chemical cross-linking to the Activation Loop, a novel locus identifying a new class of inhibitory drugs. The peptides described will be useful against a number of important diseases such as heart disease, pulmonary hypertension, arterial hypertension, glaucoma management, insulin resistance, kidney disease, hemolytic anemia, stroke, ischemia reperfusion injury, or acute myeloid leukemia.

Rho associated kinase (ROCK) inhibitors and their use in treating disease

Nucleotide triphosphate probes containing a molecular and/or atomic tag on a &#x3b3; and/or &#x3b2; phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for using the tagged nucleotides in sequencing reactions and various assay. Also, phosphate and polyphosphate molecular fidelity altering agents are disclosed.

Enzymatic nucleic acid synthesis: compositions and methods for inhibiting pyrophosphorolysis

Nucleotide triphosphate probes containing a molecular and/or atomic tag on a a &#x3b3; and/or &#x3b2; phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for using the tagged nucleotides in sequencing reactions and various assay. Also, phosphate and polyphosphate molecular fidelity altering agents are disclosed.

A method and composition for tRNA synthetases that activate and aminoacylate nonstandard and noncognate amino acids to tRNA adaptor molecules is described that can be used to generate custom designed protein products for uses in medicinal, therapeutic, diagnostic, biotechnology, engineering, and spectroscopy applications. Some tRNA synthetases naturally misactivate and misaminoacylate noncognate amino acids. Many of these tRNA synthetases, including but not limited to leucyl-, isoleucyl-, and valyl-tRNA synthetases, have evolved proofreading and editing mechanisms to correct these mistakes. Inactivation of the enzyme's editing activity allows and facilitates production and accumulation of tRNAs that are misaminoacylated with nonstandard and noncognate amino acids. These misaminoacylated tRNAs can be used to introduce novel amino acids into proteins.

Method and composition for leucyl-tRNA synthetases and derivatives thereof that activate and aminoacylate non-leucine amino acid to tRNA adaptor molecules

Antimycorbacterial compositions are disclosed comprising at least one hydroxamate or at least one hydroxamate and at least one hydroxylamine. The preferred ratio of hydroxamate to hydroxylamines is about 100:1 to about 1:1. A method for inhibiting mycobacterial growth is also disclosed comprising the step of administering the compositions of this invention to an animal including a human.

Compositions having antimycrobial activity including a hydroxamate or a hydroxamate and a hydroxlyamine

A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.

Methods for real-time single molecule sequence determination

Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity

A portable well drilling mud storage and recirculation unit includes a mud storage tank mounted on an over-the-road semi-trailer having an engine driven circulating pump mounted onboard and adapted to withdraw mud from the tank for circulation to the well and for recirculation through a set of mud agitating nozzles disposed in the bottom of the tank. A mud degassing vessel, a solids separator unit and an additive blending unit are all mounted above the tank. The degassing vessel is supported by hydraulic cylinder actuators for movement between a retracted transport position and a vertically elevated working position.

Portable drilling mud system

Growing community of inventors

Houston, TX, United States of America

James M Briggs