Other

Louisiana State University and Agricultural & Mechanical College

Oxymap Ehf.

James M Beach

Robert A Ross

Bahram Khoobehi

Einar Stefansson

Jon Atli Benediktsson

Josef K Hudson

Gisli Hreinn Halldorsson

Sveinn Hakon Hardarson

Robert Arnar Karlsson

Thor Eysteinsson

A new method was discovered to analyze continuous spectral curves to determine relative hemoglobin oxygen saturation, using spectral curves collected from a continuous range of wavelengths from about 530 nm to about 584 nm, including spectra from transmitted or reflected light. Using isosbestic points and curve areas, a relative saturation index was calculated. With this method, noninvasive, in vivo measurement of relative oxygen saturation was made using light reflected from blood vessels in the eye and to map and measure relative changes in hemoglobin oxygen saturation in primate retinal vessels and optic nerve head in response to controlled changes in inspired oxygen and intraocular pressure (IOP). This method could also measure oxygen saturation from other blood vessels that reflect light sufficient to give a clear spectra from the blood hemoglobin. Changes in blood oxygen saturation can be monitored with this method for early detection of disease.

Method for evaluating relative oxygen saturation in body tissues

The example embodiments relate to a system for automatically evaluating oxygen saturation of the optic nerve and retina, including an image capturing system which includes a fundus camera, a four wavelengths beam splitter, a digital image capturing device, a computer system, and image processing software for registering and analyzing multi-spectral images of the retina, and for evaluating oxygen saturation level.

Automatic registration of images

The disclosed light standard system provides flat field illumination through the use of an integrating light chamber which is in communication with a microprocessor. The light chamber has at least one high performance light source, such as LED's, recessed within the walls and positioned to prevent light from directly exiting the chamber. A photosensor monitors multiple parameters within the chamber and interacts with the microprocessor to control intensity, temperature and wavelengths. The lights standard operates in benchmark, ratio light, linearity and transient response modes with all parameters being programmable and storable within said microprocessor.

Light standard for microscopy

Growing community of inventors

Slidell, LA, United States of America

James M Beach