Eli Lilly and Company

Pfizer Corporation

James Lawrence Sabatowski

Kenneth Philip Moder

Nathaniel Milton

Larry Arnold Larew

Stephanie Ann Sweetana

Nathanial Milton

A complex of an echinocandin compound with a carbohydrate is described having improved thermal stability and water solubility. A process for making the echinocandin/carbohydrate complex is also described as well as the use of the complex in pharmaceutical formulations and treatments of fungal infections.

Echinocandin/carbohydrate complexes

Pharmaceutical formulations are described comprising an echinocandin compound or echinocandin/carbohydrate complex and a pharmaceutically acceptable micelle-forming surfactant in a non-toxic aqueous solvent such that the solubilization of the echinocandin compound is optimized and the ability to freeze-dry the solution is maintained. Both the solution and freeze-dried formulations have increased stability. A bulking agent, tonicity agent buffer and/or a stabilizing agent may optionally be added to the formulations to further enhance the stability of the formulation.

Echinocandin pharmaceutical formulations containing micelle-forming surfactants

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Holland, MI, United States of America

James Lawrence Sabatowski