Ortho-mcneil Pharmaceutical Corp.

American Home Products Corporation

Janssen Pharmaceutica Nv

Ortho Pharmaceutical Corporation

James Lawrence Bullington

Kenneth C Rupert

John H Dodd

Daniel A Hall

Geoffrey R Heintzelman

James Robert Henry

Sung J Lee

Terence M Dolak

Charles F Schwender

Lisa A Dixon

This invention provides novel arylindenopyridines and arylindenopyrimidines of the formula: wherein R, R, R, R, and X are as defined above, and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing adenosine A2a receptors. This invention also provides therapeutic and prophylactic methods using the instant compounds and pharmaceutical compositions.

Arylindenopyridines and arylindenopyrimidines and related therapeutic and prophylactic methods

This invention relates to novel dihydropyridine soft drugs of the formula &PHgr;OOR , where &PHgr; is a dihydropyridine moiety. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibroncho-constriction activity. Use of such soft drug analogs permits the administration of greater doses of the claimed dihydropyridine compounds without intolerable systemic effects. Thus, this invention also provides pharmaceutical compositions, as well as methods, for preventing and treating disorders such as hypersensitivity, allergy, asthma, bronchospasim, dysmenorrhea, esophageal spasm, glaucoma, premature labor, urinary tract disorders, gastrointestinal motility disorders and cardiovascular disorders, while avoiding unwanted systemic effects.

Dihydropyridine soft drugs, and related compositions and methods

This invention provides novel substituted 3-pyridyl-4-arylpyrroles, and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by reducing TNF-&agr; production and/or p38 activity in appropriate cells. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.

Substituted 3-pyridyl-4-arylpyrroles, and related therapeutic and prophylactic methods

This invention provides novel oxathiepino&lsqb;6,5-b&rsqb;dihydropyridines. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstriction activity. Thus, this invention also provides pharmaceutical compositions, as well as methods, for preventing and treating disorders such as hypersensitivity, allergy, asthma, bronchospasm, dysmenorrhea, esophageal spasm, glaucoma, premature labor, urinary tract disorders, gastrointestinal motility disorders and cardiovascular disorders.

Oxathiepino&lsqb;6,5-b&rsqb;dihydropyridines, and related compositions and methods

Benzo-fused dithiepino&lsqb;6,5-b&rsqb;pyridines, and related compositions and methods

Benzoether and related compositions and methods

Benzosulfones and related compositions and methods

This invention provides novel dithiepino&lsqb;6,5-b&rsqb;pyridines of the following formulae.

Dithiepino&lsqb;6,5-b&rsqb;pyridines, and related compositions and methods

Tetracyclic compounds having the following structure are described: ##STR1## wherein R.sub.1 -R.sub.10 are as defined. The tetracyclic compounds are capable of potent effects on steroid sensitive tissues and have demonstrated increased uterine weight, antiovulatory effects and potent steroid receptor binding. The compounds have therapeutic utility in reproductive applications such as fertility control, labor induction, ovulation induction and spermatogenesis. Methods for preparing the tetracyclic compounds from substituted indanones are also described.

Substituted dibenz (A F)azulenes and methods of preparation

This invention relates to substituted 5-pyrimidinesulfonamides, pharmaceutically acceptable salts thereof and to processes for synthesis thereof. Other aspects of the invention concern pharmaceutical compositions containing an instant compound as active ingredient and methods of treatment where there is an indicated need for an antihypertensive and/or diuretic agent.

Growing community of inventors

Hamilton Square, NJ, United States of America

James Lawrence Bullington