Mesoscale Technologies, Llc.

Harvard College

Meso Scale Technology Llp

Other

Meso Sclae Technologies, Llc.

James L Wilbur

Jacob N Wohlstadter

George B Sigal

Alan B Fischer

Mark T Martin

Eli N Glezer

Jeff D Debad

Kent Johnson

Liang-Hong Guo

Jon Leland

Bandele J Jeffrey-Coker

Charles M Clinton

Alan Kishbaugh

Mark A Billadeau

Larry Helms

Ramin Darvari

Hans Biebuyck

Satyanarayana Gudibande

George M Whitesides

Amit Kumar

Younan Xia

Enoch Kim

Milan Mrksich

Karl Kimon Berggren

Rebecca Jane Jackman

Mara G Prentiss

Christopher B Gorman

John H Kenten

Niranjan Y Sardesai

Michael Tsionsky

Robert M Umek

Paula Denney Eason

Rebecca J Jackman

Chris Gorman

Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.

Assay plates, reader systems and methods for luminescence test measurements

A method and apparatus for performing electrochemiluminescence assays are presented. In exemplary embodiments of the present invention an apparatus comprises an ECL-inactive electrode surface having a first assay-ligand immobilized thereon and an ECL-active microparticle having a second assay ligand immobilized thereon. In exemplary embodiments of the present invention a method comprises (a) forming a mixture comprising an electrochemiluminescent label and a microparticle having a first assay-ligand immobilized thereon, (b) applying electrochemical energy to an electrode surface in the presence of said mixture, and (c) measuring emitted electrochemiluminescence, where the microparticle is ECL-active and where the electrode surface is ECL-inactive when electrochemical energy is applied to it in the presence of said mixture.

Methods and apparatus for improved luminescence assays using microparticles

Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.

Methods and apparatus for conducting multiple measurements on a sample

Materials and methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for novel electrodes for ECL assays. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use multiply specific testing procedures.

Multi-array, multi-specific electrochemiluminescence testing

Materials and methods are provided for producing patterned multi-array, multi-specific surfaces which are electronically excited for use in electrochemiluminescence based tests. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use in flat panel displays and multiply specific testing procedures.

Improved methods of forming a patterned self-assembled monolayer on a surface and derivative articles are provided. According to one method, an elastomeric stamp is deformed during and/or prior to using the stamp to print a self-assembled molecular monolayer on a surface. According to another method, during monolayer printing the surface is contacted with a liquid that is immiscible with the molecular monolayer-forming species to effect controlled reactive spreading of the monolayer on the surface. Methods of printing self-assembled molecular monolayers on nonplanar surfaces and derivative articles are provided, as are methods of etching surfaces patterned with self-assembled monolayers, including methods of etching silicon. Optical elements including flexible diffraction gratings, mirrors, and lenses are provided, as are methods for forming optical devices and other articles using lithographic molding. A method for controlling the shape of a liquid on the surface of an article is provided, involving applying the liquid to a self-assembled monolayer on the surface, and controlling the electrical potential of the surface.

Methods of etching articles via microcontact printing

Growing community of inventors

Germantown, MD, United States of America

James L Wilbur