Sandia Corporation

National Technology & Engineering Solutions of Sandia, LLC

James L Van De Vreugde

Ronald Francis Renzi

Mark R Claudnic

Anup Kumar Singh

Gregory Jon Sommer

Anson Hatch

Kamlesh D Patel

Ying-Chih Wang

Steven Branda

Hanyoup Kim

Scott M Ferko

Michael S Bartsch

Todd W Lane

Stanley Alan Langevin

Victoria A VanderNoot

Zachary Bent

Embodiments of fluid distribution manifolds, cartridges, and microfluidic systems are described herein. Fluid distribution manifolds may include an insert member and a manifold base and may define a substantially closed channel within the manifold when the insert member is press-fit into the base. Cartridges described herein may allow for simultaneous electrical and fluidic interconnection with an electrical multiplex board and may be held in place using magnetic attraction.

Fluid delivery manifolds and microfluidic systems

A system for enhancing a nucleic acid sample may include a one pump, a denaturing chamber; a microfluidic hydroxyapatite chromatography device configured for performing hydroxyapatite chromatography on the nucleic acid sample, a sample collector, and tubing connecting the pump with the denaturing chamber, the hydroxyapatite chromatography device and the sample collector such that the pump may be used to move the nucleic acid sample from the denaturing chamber to the hydroxyapatite chromatography device and then to the sample collector.

Multiplexed microfluidic approach for nucleic acid enrichment

Embodiments of microfluidic hubs and systems are described that may be used to connect fluidic modules. A space between surfaces may be set by fixtures described herein. In some examples a fixture may set substrate-to-substrate spacing based on a distance between registration surfaces on which the respective substrates rest. Fluidic interfaces are described, including examples where fluid conduits (e.g. capillaries) extend into the fixture to the space between surfaces. Droplets of fluid may be introduced to and/or removed from microfluidic hubs described herein, and fluid actuators may be used to move droplets within the space between surfaces. Continuous flow modules may be integrated with the hubs in some examples.

Microfluidic hubs, systems, and methods for interface fluidic modules

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Livermore, CA, United States of America

James L Van De Vreugde