Stategics, Inc.

Elan Pharmaceuticals, Inc.

James L Miller

Timothy J Church

Juha Punnonen

Jeffrey R Spencer

Connie S Tettenborn

Karen Lariosa-Willingham

George P Miljanich

Stephen S Bowersox

Laszlo Nadasdi

Dmitri Leonoudakis

Dimitri Leonoudakis

Disclosed herein are erythropoietin-mimetic compounds of Formula I, which modulate the survival, function, or differentiation of, for example, kidney cells, neurons, erythroid cells, or other erythropoietin-responsive cells. The present invention also relates to compounds and methods that preferentially modulate cells expressing the tissue-protective erythropoietin receptor. The compounds of the invention are useful in preventing and treating diseases, such as anemia, organ injury, and diseases of the central nervous system, and as an adjunct to cellular treatments, such as stem cell therapies. 

Substituted triazolo-pyrimidine compounds for modulating cell proliferation, differentiation and survival

Substituted triazolo-pyrimidine compounds for modulating cell proliferation  differentiation and survival

Disclosed is a method of selecting analgesic agents based on their selective ability to block tetrodotoxin-insensitive sodium channels, particularly in comparison to blocking tetrodotoxin-sensitive sodium channels. Also disclosed is a novel class of compounds that is selective for blocking tetrodotoxin-insensitive sodium channels.

Analgesic screening method and composition

Growing community of inventors

Los Altos, CA, United States of America

James L Miller