Columbia University

James L Leighton

Stephen Ho

Richard Berger

Hyunwoo Kim

Corinne N Foley

Seiji Shirakawa

James Kinnaird

Deidre N O'Neil

Gregory T Notte

Xiaolun Wang

Epothilone B and dictyostatin analogs, their preparation and use

The present invention relates to a diastereomeric mixture of Silacycle Compounds and methods for using the diastereomeric mixture of Silacycle Compounds for stereoselective synthesis.

Silacycle compounds and methods of use thereof

Compositions and methods for practical, stereoselective allylation and crotylation for aldehyde substrates are described. The compositions and methods comprise reagents for allylation and/or crotylation and acids. In some embodiments, the reagents and acids are pre-mixed.

Compositions and methods for stereoselective aldehyde allylation and crotylation

A new class of reagents and method of use of the reagents in the reaction of the reagents with electrophilic compounds. The invention in one embodiment is directed to a method for the formation of an alcohol of the formula (I). The method includes reacting a reagent of the formula (II) with an aldehyde of the formula RCHO to form the alcohol. Xis one of O and C(R)(R). Each of Xand Xis independently O or N&#x2014;R. Each of Cand Cis independently an achiral center, an (S) chiral center or an (R) chiral center. Rand Rare (i) each independently Calkyl, Caryl or Cheteroaryl, or (ii) taken together to form a C&#x2014;Calkylene chain which together with Cand Cforms a 5-membered or 6-membered aliphatic ring. Rand Rare each independently hydrogen, Calkyl, Caryl or Cheteroaryl. R is Calkyl, Caryl or Cheteroaryl. Each of R, R, R, R, Ris independently hydrogen, C&#x2014;Calkyl, Caryl, Cheteroaryl, Calkoxy, Caryloxy, Cdialkylamino, Calkyl-Carylamino, Cdiarylamino, or halogen. Ris halogen, hydrogen, Calkyl, Caryl, Cheteroaryl, Calkoxy, Caryloxy, Calkyl-Carylamino, Cdiarylamino, OSOCFor SR. Rmay be Calkyl, Caryl, or Cheteroaryl. 

Reagents for asymmetric allylation, aldol, and tandem aldol and allyation reactions

The present invention provides a process for producing an optically active aldehyde which comprises hydroformylating a terminal olefin substrate represented by the formula:

Production of 3-alkoxyalkanals by hydroformylation of enol ether

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New York, NY, United States of America

James L Leighton