Burroughs Wellcome Co.

Glaxo Wellcome Inc.

Krenitsky Pharmaceuticals, Inc.

Other

Algebra, Inc.

James L Kelley

David Lee Musso

Thomas A Krenitsky

Lilia M Beauchamp

Barrett R Cooper

Grady Evan Boswell

Jeffrey Leaman Selph

Virgil L Styles

Gregory Cooksey Rigdon

James R Volpe

Ed Williams McLean

Gloria Faye Orr

Nariman Bomanshaw Mehta

Philip F Morgan

Therapeutic amine-arylsulfonamide conjugate compounds, of the general formula: 

Therapeutic amine-arylsulfonamide conjugate compounds

The present invention relates to a series of novel substituted 5-alkynyl pyrimidines, pharmaceutical compositions which contain them, methods for their preparation, and their use in therapy, particularly in the treatment of neurodegenerative or other neurological disorders of the central and peripheral nervous systems, including age related cognitive disorders such as senility and Alzheimer's disease, nerve injuries, peripheral neuropathies, and seizure disorders such as epilepsy.

Substituted 5-alkynyl pyrimidines having neurotrophic activity

The present invention relates to a series of substituted pyrimidines, to pharmaceutical compositions which contain them, to methods for their preparation and to their use in therapy, particularly in the treatment of neurodegenerative or other neurological disorders of the central and peripheral nervous systems.

Neurotrophic substituted pyrimidines

The present invention relates to novel derivatives of a series of substituted pyrimidines, to pharmaceutical compositions which contain them, to methods for their preparation and to their use in therapy, particularly in the treatment of neurodegenerative or other neurological disorders of the central and peripheral systems.

Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system

Novel compounds of formula (1) together with their salts and solvates have a number of uses in medicine, in particular as central muscle relaxants.

Bicyclic amide derivatives and their use as muscle relaxants

Novel morpholines of formula (I) and their salts, wherein R and R1 are each either hydrogen or fluorine and R2 is hydrogen or methyl. The compounds have a variety of uses in human medicine, in particular in the treatment of mental disorders such as depression. ##STR1##

Arylmorpholine preparation and use

Amide derivatives and their therapeutic use

A method for the treatment of depression in a human being, the method comprising administering to the human being an antidepressant effective amount of a compound of the following formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein R and R.sup.1 are independently hydrogen or fluorine.

Arylmorpholine, preparation and use

This invention describes the preparation and use of anticonvulsant agents. In particular, triazolopyridine compounds are described which have utility in the treatment of epilepsy in mammals.

Pharmaceutically active triazolopyridine compounds

Pharmacologically active compounds

Novel (2S, 3S, 5R) morpholinols of formula (I) ##STR1## together with the (+-)-(2R*,3R*,5S*) racemates thereof, and their salts, wherein

Heterocyclic pharmaceutical compounds and use

3-benzyl-1,2,4-triazolo [4,3-.alpha.] pyrazines are prepared. They are useful as anticonvulsants.

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Raleigh, NC, United States of America

James L Kelley