Other

3f Therapeutics, Inc.

Washington University

A.t. Still University

James L Cox

Jack M Pippin

Richard Bruce Schuessler

John P Boineau

C George Carlson

Barry H Branham

Robert D Jaquiss

Ruth P Vernon

A method of treating metastatic cancer, comprising the steps of (a) treating a metastatic cancer patient with an isolated therapeutic Cystatin C peptide, and (b) observing a reduction in tumor burden is disclosed.

Method of treating metastatic cancer

A method is disclosed for using tubular material to replace a semilunar heart valve (i.e., an aortic or pulmonary valve). To create such a replacement valve, the native valve cusps are removed from inside an aorta or pulmonary artery, and the inlet end of a tubular segment is sutured to the valve annulus. The outlet (distal) end of the tube is either &ldquo;tacked&rdquo; at three points distally, or sutured longitudinally along three lines; either method will allow the flaps of tissue between the suture lines to function as movable cusps. This approach generates flow patterns that reduce turbulence and closely duplicate the flow patterns of native semilunar valves. An article of manufacture is also disclosed, comprising a sterile biocompatible synthetic material which has been manufactured in tubular form, by methods such as extrusion or coating a cylindrical molding device, to avoid a need for a suture line or other seam to convert a flat sheet of material into a tubular shape. The synthetic tube is packaged within a sealed watertight enclosure that maintains sterility of the tube.

Replacement semilunar heart valve

A replacement heart valve is configured to replace a native atrioventricular heart valve (mitral or tricuspid valve, positioned between an atrial chamber and a ventricular chamber). The replacement valve includes a a thin and flexible wall portion having no more than two leaflets. Two securement locations adjacent the outlet end of the valve are adapted to be attached to respective papillary muscles. The unconstrained regions between the securement locations flex inwardly into and out of engagement with each other in response to blood pressure in order to close and open the valve. The leaflets engage each other along a line of commissure.

Replacement atrioventricular heart valve

A prosthetic heart valve has leaflets made of a thin and flexible material. The side edges of adjacent leaflets are sewn together so as to form a substantially tubular valve structure having an in-flow end and an out-flow end. Each of the leaflets is adapted to flex inwardly into and out of engagement with another leaflet so as to close and open the valve in response to force by blood pressure. The leaflets are configured so that a portion of the inner face of each leaflet is in a facing relationship with a portion of the inner face of an adjacent leaflet.

Replacement heart valve

A method is provided for inhibiting and substantially decreasing the motility of cells, and especially melanoma cells. In the invention, a cell is contacted with a motility-inhibiting amount of a metal ion selected from the group consisting of cobalt ion, the lanthanide metal ions, and mixtures thereof; particularly preferred metal ions are the Co and Gd ions. Metal ion sources may be administered in the form of soluble metal halide salts to in vitro to cells dispersed in an aqueous saline medium, or by administering an aqueous dispersion thereof to an in vivo mammalian subject at or adjacent a tumor site.

Methods for inhibiting cell motility

Replacement semilunar heart valves using flexible tubes

A method is disclosed for using tubular material to replace a semilunar heart valve (i.e., an aortic or pulmonary valve). To create such a replacement valve, the native valve cusps are removed from inside an aorta or pulmonary artery, and the inlet end of a tubular segment is sutured to the valve annulus. The outlet (distal) end of the tube is either 'tacked' at three points distally, or sutured longitudinally along three lines; either method will allow the flaps of tissue between the suture lines to function as movable cusps. This approach generates flow patterns that reduce turbulence and closely duplicate the flow patterns of native semilunar valves. An article of manufacture is also disclosed, including a sterile biocompatible synthetic material which has been manufactured in tubular form, by methods such as extrusion or coating a cylindrical molding device, to avoid a need for a suture line or other seam to convert a flat sheet of material into a tubular shape. The synthetic tube is packaged within a sealed watertight enclosure that maintains sterility of the tube.

This invention comprises a method of using tubular material to replace an atrioventricular (AV) heart valve (i.e., a mitral or tricuspid valve, positioned between an atrial chamber and a ventricular chamber) during cardiac surgery. Preferably, the tubular material should be inherently tubular; i.e., it should be created in tubular form from its inception, rather than by using a longitudinal suture line or other seam to convert a flat sheet of material into a tubular shape. Suitable tubular materials include (1) biocompatible synthetic materials which are manufactured in tubular form, by methods such as extrusion or coating a cylindrical molding device, using material which is sufficiently thin and flexible to serve as leaflets in AV heart valves; and (2) a segment of submucosal tissue harvested from a small intestine, either from the patient who is undergoing the cardiac surgery, or from an animal or human cadaver if the harvested tissue is properly treated to reduce antigenicity. To create a replacement AV valve, the inlet of the tubular segment is sutured to the mitral or tricuspid valve annulus, after the native valve leaflets have been removed. The outlet end of the tube is trimmed or sculpted into leaflets, and the distal ends of the leaflets are sutured to papillary muscles in the ventricle, in a manner which causes the leaflets to 'approximate' (close together), during systolic contraction of the heart, in a configuration that resembles the line of commissure created by healthy native leaflets. This generates flow patterns that closely duplicate the flow patterns of native AV valves.

Method of replacing atrioventricular heart valves using flexible tubes

This invention comprises a method of using tubular material to replace a heart valve during cardiac surgery. To create a replacement atrioventricular (mitral or tricuspid) valve, the tube inlet is sutured to a valve annulus from which the native leaflets have been removed, and the tube outlet is sutured to papillary muscles in the ventricle. To create a semilunar (aortic or pulmonary) valve, the tube inlet is sutured to an annulus from which the native cusps have been removed, and the tube is either 'tacked' at three points distally inside the artery, or sutured longitudinally along three lines; this allows the flaps of tissue between the three fixation points at the valve outlet to function as movable cusps. These approaches generate flow patterns that closely duplicate the flow patterns of native valves. One preferred tubular material comprises submucosal tissue from a small intestine, from the same patient who is undergoing the cardiac operation; this eliminates the risk of immune rejection and the need to treat the tissue to reduce antigenicity. Intestinal tissue from human cadavers or animals such as genetically engineered hypoallergenic pigs can also be used, if properly treated, or a biocompatible synthetic tubular material can be used.

Method of replacing heart valves using flexible tubes

An optimal electrophysiologic mapping system for map-directed arrhythmia surgery and cardiac research allows rapid and accurate interpretation of cardiac activation sequences. The system can display activation or potential distribution data on an anatomically accurate 3-D model of the heart and allows fast, interactive control of viewing characteristics, including control of which cardiac surfaces are displayed, control of virtual lighting, rotational control of the displayed image, etc. The system employs two computer programs, GETPIC3 and MAP3, and runs on a Silicon Graphics workstation capable of rapid graphics calculations and displays. The system utilizes 3-D models of epicardial and endocardial surfaces created with the GETPIC3 program from a sequence of 2-D images of a heart. The individual surfaces are triangulated and may be smoothed using a spline function. The MAP3 program displays activation times either as static isochronous maps or as dynamic time-since-last-activation maps. In the latter case, surface color denotes the time elapsed since a particular area activated. Potential distribution data may also be displayed dynamically. A mouse allows the system operator to control real-time rotation of the model in three dimensions, and any surface can be hidden interactively for better viewing of the data. Control is also provided over the starting, stopping, reversing, and repeating of data, as well as over the frame rate for dynamic displays.

Computerized three-dimensional cardiac mapping with interactive visual

This invention comprises a method of using tubular material to replace a heart valve during cardiac surgery. To create a replacement atrioventricular (mitral or tricuspid) valve, the tube inlet is sutured to a valve annulus from which the native leaflets have been removed, and the tube outlet is sutured to papillary muscles in the ventricle. To create a semilunar (aortic or pulmonary) valve, the tube inlet is sutured to an annulus from which the native cusps have been removed, and the tube is either 'tacked' at three points distally inside the artery, or sutured longitudinally along three lines; this allows the flaps of tissue between the three fixation points at the valve outlet to function as movable cusps. These approaches generate flow patterns that closely duplicate the flow patterns of native valves. A preferred tubular material comprises submucosal tissue from the small intestine of the same patient who is undergoing the cardiac operation. By using tissue from the same patient, the risk of immune rejection and the need to treat the tissue to reduce antigenicity are eliminated. Animal or human cadaver intestinal tissue can also be used if properly treated, or a biocompatible synthetic tubular material can be used. This invention also discloses a properly treated intestinal tissue segment or synthetic tubular segment suitable for implantation as a replacement heart valve, enclosed in a sealed sterile package.

Heart valve replacement using flexible tubes

This invention provides a device and method for cooling an internal organ during surgery. The device involves a porous, water-permeable net, preferably made of hydrophilic elastic fabric. The net is fitted and secured around the organ and cold saline solution is infused into the net, preferably by means of a side-hole catheter. The cold liquid passes through the net, directly contacting and chilling the organ. As the liquid drips out of the net, it is removed from the patient's chest or abdomen by suction tube. To provide convenient access to any location on the surface of the organ (for example, to operate on a coronary artery which must be bypassed) a cut is made through a part of the net overlying the location that must be operated on. This exposes the artery without affecting the ability of the net to cool the rest of the organ. The cooling net described herein also provides a method of cooling the atrial region of a heart during surgery, by means of a segment of porous tubing positioned in the atrial region of the heart. Part of the cold liquid diffuses out of the porous tubing and chills the atrial region, while the rest of the cold liquid permeates through the net and chills the ventricular region.

Cooling net for cardiac or transplant surgery

A garment having differential thermal properties for retaining heat adjacent to the arm and shoulder muscles of an athlete, while allowing the remaining body muscles to naturally cool. The garment comprises a sleeve for covering the arm and a skirt attached to the sleeve for covering the deltoid, pectoral and tarus major and minor muscles adjacent the throwing arm. A coupler is provided for removably attaching the skirt and sleeve to the uniform of the athlete. In a first preferred embodiment this coupler may be a plurality of Velcro patches.

Growing community of inventors

Ladue, MO, United States of America

James L Cox