Diagnostic Hybrids, Inc.

Other

Intherthyr Corporation

James L Brown

David R Scholl

Joseph A Jollick, Jr

Leonard D Kohn

Ronald Lollar

Rodolfo Garcia

Francesco Saverio Ambesi-Impiombato

Joseph A Jollick

Yunsheng Li

Giorgio Napolitano

Joseph Jollick

Leonard Kohn

David Scholl

The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease, but also improve upon the sensitivity and detection abilities of previous luciferase-based autoantibody detection assays. Such improvements are based upon the superior performance of assays comprising a chimeric TSH receptor in the presence of a glucocorticoid including, but not limited to, dexamethasone.

Sensitive and rapid methods of using chimeric receptors to identify autoimmune disease and assess disease severity

The present invention describes a liquid direct fluorescence antibody assay that is rapid and sensitive to detect respiratory virus in infected cells. The assay includes centrifugation of the specimen, incubation of sample and reagents in solution, and detection of the absence or presence of respiratory virus. Sapogenin is used as a detergent to permeabilize the cells for entry of the monoclonal antibodies to react with intracellular antigens. The cells are stained with fluorescently labeled monoclonal antibodies against the viral antigens along with a background stain and a fluorescent nuclear stain. This counter staining decreases background and allows co-localization of antigen and nuclear structures for enhanced detection.

Methods for liquid direct fluorescent antibody intracellular virus detection

The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease, but also improve upon the sensitivity and detection abilities of previous luciferase-based autoantibody detection assays.

Methods of using chimeric receptors to identify autoimmune disease

Methods for direct fluorescent antibody virus detection in liquids

Improvements in present day fire hydrants are presented. The improvement relates to a fire hydrant where the above ground structure is essentially removed and is replaced with an adaptable connection. The connection uses the same mounting hole pattern as used in the above ground hydrant. In operation, the adaptable connection is protected by a hinged cover that is opened to provide access to the adaptable connection. The adaptable connection includes a bayonet type connection where a portable fire hydrant is secured and rotated to start the flow of water. The adapter includes an electronic communication device that transmits real-time information on connection and flow characteristics. The adaptable fire connection eliminates the appearance of the fire hydrant, the potential of a vehicle hitting a fire hydrant and the material cost associated with above ground fire hydrants.

Adaptable water connection for fire fighting equipment and connection device

Improvements in present day fire hydrants are presented. The improvement relates to a fire hydrant where the above ground structure is essentially removed and is replaced with an adaptable connection. The connection uses the same mounting hole pattern as used in the above ground hydrant. In operation, the adaptable connection is protected by a hinged cover that is opened to provide access to the adaptable connection. The adaptable connection includes a bayonet type connection where a portable fire hydrant is secured and rotated to start the flow of water. The adaptable fire connection eliminates the appearance of the fire hydrant, the potential of a vehicle hitting a fire hydrant and the material cost associated with above ground fire hydrants.

The present invention provides methods and compositions for the in situ growth, freezing and testing of cultured cells. In particular, the present invention provides methods and compositions for the long-term preservation of cells in ready-to-use formats for testing. In addition, the present invention provides rapid and easy to use means to diagnose viral and other infections. Furthermore, the present invention provides easy to use means to grow and store cells in situ for testing methods. Indeed, the present invention makes viral, chlamydial and other diagnostic methods accessible to small laboratories, including those without cell culture capabilities.

In situ growth, freezing and testing of cultured cells

The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention avoid the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease.

Diagnosis of autoimmune disease

This invention is a new designed configuration of a laminated folding navigation chart. This said chart is intended for pilots and navigators of small planes and watercraft. This said navigation chart consists of a plurality of (preferably 10) panels that are flexibly coupled together at their contiguous edges. The said transparent flexible couplings herein described allow epicycle multiplicity folding of said panels relative to each other. This said epicycle multiplicity folding of panels allows the chart to be viewed clearly while in the fully open position, partial open position or in a single panel closed position.

Flip-flop float chart

A soft flying game disc comprising a limp, generally circular fabric locally annularly stiffened inwardly of the fabric peripheral edge margin in central air foil and peripheral spoiler skirt structure defining relation.

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Athens, OH, United States of America

James L Brown