Vanderbilt University

James Kintzing

Craig L Duvall

Mukesh Kumar Gupta

Scott A Guelcher

Jeffrey M Davidson

Christopher E Nelson

Joshua M Shannon

Elizabeth J Adolph

The presently-disclosed subject matter includes nanoparticles that comprise a plurality of assembled polymers. In some embodiments the polymers comprise a first block that includes hydrophilic monomers, the first block substantially forming an outer shell of the nanoparticle, and a second block that includes cationic monomers and hydrophobic monomers, the second block substantially forming a core of the nanoparticle. In some embodiments a polynucleotide is provided that is bound to the cationic monomers of the nanoparticle. The presently-disclosed subject matter also comprises methods for using the present nanoparticles to include RNAi in a cell as well as methods for making the present nanoparticles.

Polymeric nanoparticles

Growing community of inventors

Nashville, TN, United States of America

James Kintzing