Imperial Chemical Industries Limited

James Kenneth Sutherland

Gareth Morse Davies

William J Watkins

Richard Philip Peel

George A Snow

6-Fluoroshikimic acid derivatives of the formula (I): ##STR1## wherein R.sup.1 is hydroxy or a moiety biotransformable thereto and R.sup.2 is hydrogen or --P(O)(OH).sub.2 have antibacterial, antifungal and herbicidal activity. Their preparation and use are described as are pharmaceutical compositions containing them.

Compounds useful as intermediates in the synthesis of shikimic acid

6-Fluoroshikimic acid derivatives of the formula (I): ##STR1## wherein R.sup.1 is hydroxy or a moiety biotransformable thereto and R.sup.2 is hydrogen or --P(O)(OH).sub.2 have antibacterial, antifungal, and herbicidal activity. Their preparation and use are described as are pharmaceutical compositions containing them.

6-Fluoro-shikimic acid derivatives, pharmaceutical compositions and use

The disclosure relates to a series of novel prostaglandin intermediates, the preparation of which in sequence constitutes a novel process for the manufacture of known diol intermediates, for example 2,3,3a.beta.,6a.beta.-tetrahydro-5.alpha.-hydroxy-4.beta.-(3-hydroxyoct-1- trans-enyl)-2-oxocyclopenteno[b]furan, from the readily available norbornadiene, said process comprising fewer and more easily operable stages than previously known processes for the manufacture of said diol intermediates.

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Manchester, United Kingdom

James Kenneth Sutherland