Glaxo Laboratories Limited

James Kennedy

Alan Gibson Long

Niall Galbraith Weir

John Colin Clark

Stephen Eardley

The invention is concerned with the preparation of .DELTA..sup.3 -4-carboxy cephalosporin antibiotics possessing a 3-vinyl group or substituted 3-vinyl group by means of phosphorous intermediates.

Process for the preparation of 3-vinyl and substituted vinyl

The invention is concerned with .DELTA..sup.3 -4-carboxy cephalosporin antibiotics possessing a 3-vinyl or substituted 3-vinyl groups as well as with phosphorous intermediates useful in the preparation thereof.

.DELTA..sup.3 -3-Vinyl or substituted vinyl-4-carboxy cephalosporins

7.beta.-Amino- and acylamidoceph-3-em-4-carboxylic acids having at the 3-position a halo-, formyloxy-, isothiocyanato- or haloacetoxymethyl group and salts and esters thereof. These compounds are useful as starting compounds for preparing 7.alpha.-acylamidoceph-3-em-4-carboxylic acids having a group at the 3-position, other than 3-acetoxymethyl, by reaction with a nucleophile. The compounds prepared have modified antibiotic activity.

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Angus, United Kingdom

James Kennedy