The Johns Hopkins University

University of Pittsburgh

James K Johnson

Christopher M Hoffman, Jr

Peter Wipf

Joel Byron Nelson

Zhiyong Xia

Zhou Wang

Erin M Skoda

Serene Tai

Keita Takubo

John Milligan

Konstantinos Gerasopoulos

Spencer A Langevin

Adam W Freeman

Felix C Sage

Reid E Messersmith

Contaminant-sequestering coatings include a network of hydrolyzed silane compounds including (i) a plurality of fluorinated functionalities, and (ii) a plurality of thiol functional groups are provided. The network of hydrolyzed silane compounds includes a fluorinated silane including (a) a hydrophilic polar head region. The polar head region includes one or multiple units of ethylene glycol (EG) functionality, (b) a fluorine-containing region, and (c) an anchor region including a silicon atom. The contaminant-sequestering coatings may sequester one or more per- and polyfluoroalkyl substances (PFAS), heavy metals, biological species, or any combination thereof.

Contaminant-sequestering coatings and methods of using the same

Contaminate-sequestering coatings including a network of hydrolyzed silane compounds including a plurality of thiol functional groups, a plurality of fluorinated functionalities, or both are provided. The contaminate-sequestering coatings may sequester one or more per- and polyfluoroalkyl substances (PFAS), heavy metals, biological species or any combination thereof. Methods of functionalizing a substrate surface with contaminate-sequestering functionalities that sequester one or more PFAS, heavy metals, or both are also provided. Methods of removing contaminants from contaminate-containing liquids, and devices including the contaminate-sequestering coatings are also provided.

Contaminate sequestering coatings and methods of using the same

A compound, or a pharmaceutically acceptable salt or ester thereof, according to formula I:R&#x2014;(Z)&#x2014;(Y)&#x2014;(R)&#x2014;(X)&#x2014;R&#x2014;Rwherein Ris aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; Z is alkanediyl, substituted alkanediyl, cycloalkanediyl, or substituted cycloalkanediyl; Y is S, O, S(&#x2550;O), &#x2014;S(&#x2550;O)(&#x2550;O)&#x2014;, or NR, wherein Ris H or alkyl; Ris alkanediyl, substituted alkanediyl, cycloalkanediyl, substituted cycloalkanediyl, alkadienyl, substituted alkadienyl, cycloalkenediyl, substituted cycloalkenediyl, alkatrienyl, substituted alkatrienyl; X is &#x2014;C(&#x2550;O)&#x2014;, &#x2014;S(&#x2550;O)(&#x2550;O)&#x2014;, or &#x2014;N(H)C(&#x2550;O)&#x2014;; Rincludes at least one divalent amino radical; Ris aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; a, b, c, and d independently are 0 or 1.

Small molecule inhibitors of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer

An anti-fouling coating comprising a polymeric compound, wherein a backbone of the polymeric compound is covalently bonded to a quorum sensing inhibitor, and wherein the anti-fouling coating has substantially no bactericidal activity, the quorum sensing inhibitor is substantially non-leaching from the anti-fouling coating, or both.

Anti-microbial coating for the prevention of biofouling

A compound, or a pharmaceutically acceptable salt or ester thereof, according to formula I:R&#x2014;(Z)&#x2014;(Y)&#x2014;(R)&#x2014;(X)&#x2014;R&#x2014;Rwherein Ris aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; Z is alkanediyl, substituted alkanediyl, cycloalkanediyl, or substituted cycloalkanediyl; Y is S, O, S(&#x2550;O), &#x2014;S(&#x2550;O)(&#x2550;O)&#x2014;, or NR, wherein Ris H or alkyl; Ris alkanediyl, substituted alkanediyl, cycloalkanediyl, substituted cycloalkanediyl alkadienyl, substituted alkadienyl, alkatrienyl, substituted alkatrienyl; X is &#x2014;C(&#x2550;O)&#x2014;, &#x2014;S(&#x2550;O)(&#x2550;O)&#x2014;, or &#x2014;N(H)C(&#x2550;O)&#x2014;; Rincludes at least one divalent amino radical; Ris aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; a, b, c, and d independently are 0 or 1.

Steering wheel

Growing community of inventors

Silver Spring, MD, United States of America

James K Johnson